NGAL in chronic kidney disease: clinical studies. As discussed above, NGAL is a promising biomarker of AKI. In CKD, there is a growing literature suggesting that NGAL is also a marker of kidney disease and severity.

2022年11月1日 · Neutrophil Gelatinase Associated Lipocalin (NGAL) is a secretory protein of neutrophils that can be found both in plasma and urine. Previous works have demonstrated a valuable marker for the early detection of acute kidney injury.

Studies in the domestic and abroad have revealed that during the initiation and development of kidney disease such as acute kindey injury (AKI) and chronic kidney disease (CKD), changes in NGAL levels can be detected in urine and blood before the …

急性肾损伤（AKI）是一种涉及多学科的临床常见危重病，由多种病因造成肾功能在短期内急性减退，临床上对AKI也不是无计可施，NGAL成为发现AKI的早期标志物。 什么是NGAL? 名称：neutrophil gelatinase associated lipocalin；中性粒细胞明胶酶相关脂质运载蛋白

2024年7月30日 · 研究显示，慢性肾病（ckd）患者尿液、血浆中的ngal水平显著高于正常人群，并与肾小球滤过率(gfr)及肾实质损伤的严重程度密切相关，因此，ngal可作为评价ckd患者肾脏损伤程度的标志物。

Estimated glomerular filtration (eGFR) rate was calculated by Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula. The patients were followed for two years to determine the ability of baseline NGAL for prediction of renal outcome.

2020年5月26日 · We found that uNGAL measured at the onset of AKI was associated with persistent AKI, MAKE30, MAKE365, new-onset CKD, and CKD progression. Urinary NGAL performed better than other markers for...

Each 10 ng/mL higher urinary NGAL or serum NGAL was associated with a 3% (HR, 1.03; 95% CI, 1.03–1.04) and 2% (HR, 1.02; 95% CI, 1.01–1.03) higher risk for progression of CKD (31 cases), defined as doubling of serum creatinine or development of ESRD, respectively, after adjustment for age and baseline eGFR. No previous studies to our ...

2022年1月21日 · 肾功能下降可发生在原来无肾功能不全的患者，也可发生在原已稳定的慢性肾病（CKD）患者，其主要发病原因是肾灌注量减少导致血流动力学介导的肾小球滤过率降低引起肾脏局部缺血和再灌注损伤，但不存在肾实质损伤。 如果能及时纠正肾灌注量减少，则能逆转血流动力学损害，使肾功能迅速恢复，否则可发生细胞明显损伤而导致急性肾小管坏死（ATN）。 随着科技的发展，临床的治疗及监护水平均有了很大提高，但AKI及其由此引发的合并症发病率仍居高 …

The evidence for the role of NGAL measurements in a variety of clinical situations leading to AKI (cardiac surgery, kidney transplantation, contrast nephropathy, haemolytic uraemic syndrome and in the intensive care setting) or to CKD (lupus nephritis, glomerulonephritides, obstruction, dysplasia, polycystic kidney disease, IgA nephropathy) is ...