The types are the clinical pictures of CMT (CMT type 1, 2, 4, X, etc.), usually defined by inheritance pattern and nerve conductions. Subtypes (CMT1A, 2B, 4C, X1, etc.) are given only when the genetic cause is known.

Unlike CMT1, which results from damage to the myelin sheath insulating axons, CMT2 is caused by direct damage to nerve axons themselves. CMT2 is commonly referred to as “axonal” CMT. CMT2A is the most common subtype of CMT2 (it accounts for 20% of the cases of axonal CMT) and is caused by defects in the MFN2 gene.

CMT Type 1 (CMT1) is defined as an autosomal dominant demyelinating form of Charcot-Marie-Tooth disease. Learn more about CMT1 and subtypes.

CMT Type 2 represents axonal forms of Charcot-Marie-Tooth disease that are dominantly inherited and make up about one-third of all dominant CMT cases. Patients with Type 2 have a …

2018年10月8日 · Results: The CMT1 group was significantly greater for age, height and body mass in comparison to the CMT2 group (Table 1). The CMT1 group also showed significantly increased step lengths and walking velocity than the CMT2 group.

To evaluate the clinical and electrophysiological similarities and differences between two large groups of patients with Charcot-Marie-Tooth disease, i.e. CMT1A and CMT2, we performed a post hoc comparison of clinical and electrophysiological data. Most CMT1A and CMT2 patients had the classical CMT …

2006年8月28日 · To evaluate the clinical and electrophysiological similarities and differences between two large groups of patients with Charcot-Marie-Tooth disease, i.e. CMT1A and CMT2, we performed a post hoc comparison of clinical and electrophysiological data. Most CMT1A and CMT2 patients had the classical CMT phenotype.

The most prominent CMT subtypes identified in our clinic were CMT1A, CMT1X, HNPP, CMT1B, and CMT2A (Table 1). All other CMT subtypes accounted for less than 1% of all patients with genetically defined CMT each. Only 1.8% of patients with CMT1 were without a genetic diagnosis.

Different types of CMT are grouped together based on how they are inherited and the precise piece of the nervous system that is dysfunctional. Learn about Type 1 Charcot-Marie-Tooth …

CMT Type 2 represents axonal forms that are dominantly inherited and make up about one-third of all dominant CMT cases. The clinical presentation is similar to Type 1: distal weakness, muscle atrophy, sensory loss and foot deformities.