CNF1 is an AB-type toxin, composed of the N-terminal cell binding domain and the C-terminal catalytic domain possessing a deaminase activity through the site-specific deamination of a …

2025年1月29日 · Results: CNF1 induces the release of reactive oxidizing species and chromosomal instability in non-neoplastic intestinal epithelial cells. In addition, CNF1 modifies …

Cytotoxic necrotizing factor 1 (CNF1) is a toxin whose structure from Escherichia coli revealed a 4-layer alpha/beta/beta/alpha structure containing mixed beta-sheets. [1] CNF1 is expressed …

The cytotoxic necrotizing factor 1, from uropathogenic Escherichia coli, is the paradigm of Rho-GTPases-activating bacterial toxins. CNF1 is a MW 108kDa A-B protein toxin divided into …

2025年1月29日 · CNF1 is a protein toxin that permanently activates Rho GTPases (Rho, Rac and Cdc42), molecular switches involved in regulating a wide range of cell signaling pathways.

2001年11月1日 · CNF1 is a MW 108 kDa A-B protein toxin divided into three domains which are implicated in the three steps of the intoxication process. The N-terminal domain contains the …

In the present review, we summarized the key studies addressing the immunomodulatory functions of CNF1 and discussed the contribution that CNF1 can bring about to CRC through …

2014年1月7日 · CNF1 is a single-chain multidomain protein that contains a N-terminal receptor-binding domain, a translocation domain (middle domain) and a C-terminal catalytic domain, …

CNF1 is a protein toxin produced by certain pathogenic strains of Escherichia coli. It permanently activates the regulatory Rho, Rac, and Cdc42 GTPases in eukaryotic cells, by deamidation of …

CNF1 is a single chain multidomain protein toxin that contains a binding domain at the N-terminus, a central translocation domain, and an enzymatic domain at C-terminus. CNF1 …