CNPase is a myelin -associated enzyme that makes up 4% of total CNS myelin protein, and is thought to undergo significant age-associated changes. [7] It is named for its ability to catalyze the phosphodiester hydrolysis of 2',3'-cyclic nucleotides to 2'-nucleotides, though a cohesive understanding of its specific physiologic functions are still ...

神经元是中枢神经系统 (CNS) 和周围神经系统 (PNS) 中的电兴奋细胞，它们传送并接收电脉冲和神经化学信号以处理信息。 神经元驱动脑、脊髓、外周感觉和运动系统中的活动。 它们是高度特化的细胞，能够在突触间快速传送电信号和神经递质。 虽然神经系统中存在各种各样的神经元类型和形态，但信号通常在细胞体或树突上接收，并沿轴突发出。 通常通过观察细胞特异性胞内蛋白的表达来确定神经元，如神经元胞核 (NeuN)、β3-微管蛋白和泛素 C 末端水解酶-1 (UCHL1)。 …

2016年6月15日 · CNPase is a peripheral membrane protein containing two folded domains and a lipidated tail. It has a specific enzymatic activity first discovered 60 years ago (Drummond et al., 1962, Whitfeld et al., 1955), and only recently, possible endogenous substrates have been discovered (Verrier et al., 2012).

The membrane-anchored myelin enzyme 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) was discovered in the early 1960s and has since then troubled scientists with its peculiar catalytic activity and high expression levels in the central nervous system.

2012年2月29日 · CNPase is a member of the 2H phosphoesterase family and catalyzes the formation of 2′-nucleotide products from 2′,3′-cyclic substrates; however, its physiological substrate and function remain unknown. It is likely that CNPase participates in RNA metabolism in the myelinating cell.

2015年11月13日 · 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNPase) is an enzyme highly abundant in the central nervous system myelin of terrestrial vertebrates. The catalytic domain...

2024年12月10日 · 2′,3′-Cyclic nucleotide 3′-phosphodiesterase (CNPase) is an abundant constituent of central nervous system non-compact myelin, and its loss in mice and humans causes neurodegeneration. Additionally, CNPase is frequently used as a marker antigen for myelinating cells.

2'2'—环核苷酸3'—磷酸二酯酶 (CNPase)是一种髓鞘标志酶,主要存在于CNS髓鞘,其他组织中活性很低.动物实验及临床研究表明,当CNS发生脱髓鞘损害时,CNS髓鞘中CNPase活性降低,CNPase释放进入CSF.因而测定病人的CSFCNPase活性,有助于脱髓鞘疾病,尤其是对多发性硬化 (MS)的 ...

2015年9月15日 · 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) is an abundant membrane-associated enzyme within the vertebrate myelin sheath. While the physiological function of CNPase still remains to be characterized in detail, it is known - in addition to its in vitro enzymatic activity - to interact with …

2′,3′-cyclic nucleotide-3′-phosphodiesterase (CNPase) is a myelin-associated enzyme that catalyzes the phosphodiester hydrolysis of 2’,3’-cyclic nucleotides to 2’-nucleotides. However, its presence is also found in unmyelinated cells and other ...