Prediction and prevention of central nervous system relapse in …
2020年11月26日 · The CNS-PINK was demonstrated its strong predictability of CNS relapse in ENKTL patients. The effectiveness of S-ID-MTX in preventing CNS events in high-risk CNS-PINK patients should be verified in future studies.
Is the CNS-PINK the new CNS risk model in ENKTL?
2020年11月26日 · In summary, the CNS-PINK is the first step forward to a CNS risk model in ENKTL. Further validation studies and investigation of the protective effect of MTX and other CNS penetrant agents are eagerly awaited.
Central Nervous System Progression/Relapse in Mature T- and NK …
The same group published an updated report in order to create a predictive model for CNS progression/relapse in patients with ENKTL called the CNS-prognostic index of natural killer (CNS-PINK) model . They had a training cohort of 399 patients with ENTKL, of which 6.8% (n = 27) developed CNS progression/relapse. Of patients with CNS disease, 11 ...
Bood：结外自然杀伤/T细胞淋巴瘤患者CNS复发的预测和预防
2022年6月25日 · Kim等人开发了一种新的CNS-PINK模型，对ENKTL患者的CNS复发具有很强的预测能力；S-ID-MTX预防CNS-PINK高危患者CNS事件的能力值得进一步验证。 由于L-天冬酰胺酶非蒽环类化疗改善了结外自然杀伤/T细胞 淋巴瘤 (ENKTL)患者的生存预后，中枢神经系统 (CNS)复发的发生率与既往报道的不同。 在本研究中， 研究人员旨在明确CNS复发的发生率和预测标志物，以评估中剂量MTX（ID-MTX） 预防 CNS的必要性。 回顾分析了训练队列的399例 …
Prediction and prevention of central nervous system relapse in …
2020年11月26日 · A new central nervous system-prognostic index of natural killer (CNS-PINK) model was developed using 1-point powerful predictors of CNS relapse (PINK; hazard ratio [HR], 2.908; P = .030 and extranodal involvement [≥2]; HR, 4.161; P = .001) and was calculated as a sum of scores. The high-risk group of CNS-PINK was defined as 2 points.
Number of Sites of Involvement Predicts Central Nervous System …
2024年11月5日 · The CNS-Prognostic Index of Natural Killer (CNS-PINK) model is widely used to predict CNS relapse (Kim H. Blood, 2020). The relationship between the number of sites of involvement and CNS relapse in ENKL remains unclear. First-line treatment approaches differ between localized and advanced ENKL.
Improved prognosis of advanced-stage extranodal NK/T-cell …
2025年2月17日 · All 4 patients who experienced CNS relapse after responding to chemotherapy were classified as high-risk according to the CNS-PINK. Notably, 2 of the 4 patients had involvement of both adrenal...
Overview of the current treatment strategy in extranodal NK/T-cell ...
Consequently, researchers have developed a prognostic index of natural killer lymphoma (PINK)/PINK-E (EBV) and central nervous system (CNS)-PINK. With objective and weighted scoring systems, we can segment the treatments applied to patients and predict their prognosis more accurately (14, 15).
Is the CNS-PINK the new CNS risk model in ENKTL? - PubMed
2020年11月26日 · Is the CNS-PINK the new CNS risk model in ENKTL? Is the CNS-PINK the new CNS risk model in ENKTL? Is the CNS-PINK the new CNS risk model in ENKTL? Blood. 2020 Nov 26;136(22):2486-2487. doi: 10.1182/blood.2020007567. Authors Fredrik Ellin 1 , Kerry J Savage 2 Affiliations ...
Peripheral T-Cell Lymphomas Involving the Central Nervous …
A new CNS prognostic index of natural killer lymphoma (CNS-PINK) was developed for patients with ENKTCL treated with non-anthracycline-based chemotherapy (19). A sum of scores was calculated using one-point predictors of CNS relapse (B symptoms, stage III or IV, and distant lymph-node involvement) and extranodal involvement.