2025年3月5日 · Collagen type IV alpha 1 (COL4A1) and 2 (COL4A2) are extracellular matrix proteins that together constitute a major component of nearly all basement membranes of the …

2024年12月24日 · COL4A2 (Collagen Type IV Alpha 2 Chain) is a Protein Coding gene. Diseases associated with COL4A2 include Brain Small Vessel Disease 2 and Hemorrhage, …

Heterotrimers composed of collagen type IV alpha 1 (COL4A1) and alpha 2 (COL4A2) constitute one of the most abundant components of nearly all basement membranes. Accordingly, …

它由六个不同的基因编码： IV型胶原蛋白 α1 (COL4A1)、 COL4A2 、 COL4A3 、 COL4A4 、 COL4A5 和 COL4A6。 1.临床意义. IV型胶原蛋白可维持细胞分裂和生长。 胶原蛋白分泌异常 …

dominant COL4A2 mutations are a novel major risk factor for familial cerebrovascular disease, including porencephaly and small-vessel disease with reduced penetrance and variable …

2019年9月4日 · Type IV collagen is associated with laminin, entactin, and heparan sulfate proteoglycans to form the sheetlike basement membranes that separate epithelium from …

Collagen alpha-2(IV) chain is a protein that in humans is encoded by the COL4A2 gene. [5] [6] [7] This gene encodes one of the six subunits of type IV collagen, the major structural component …

2012年10月15日 · Heterotrimers composed of collagen type IV alpha 1 (COL4A1) and alpha 2 (COL4A2) constitute one of the most abundant components of nearly all basement …

该基因编码 IV 型胶原蛋白的六个亚基之一，IV 型胶原蛋白是基底膜的主要结构成分。 该蛋白质的 C 末端部分称为 canstatin，是血管生成和肿瘤生长的抑制剂。 与 IV 型胶原蛋白基因家族的其 …

De novo and inherited mutations in COL4A2, encoding the type IV collagen α2 chain cause porencephaly. COL4A2 mutations impair COL4A1 and COL4A2 secretion and cause …