PPARγ inhibits small airway remodeling through mediating the ...
The role of Peroxisome Proliferator-Activated Receptor-γ (PPARγ) in alveolar macrophages(AMs) polarization homeostasis is closely associated with airway remodeling in COPD, but the …
PPARγ attenuates cellular senescence of alveolar macrophages
2024年4月20日 · Background: Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) represents a complex condition characterized by shared clinical and pathophysiological …
Role of GPx3 in PPARγ-induced protection against COPD ... - PubMed
Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear hormone receptor with antioxidant effects. PPARγ activation has demonstrated protective effects against cigarette …
PPARγ inhibits small airway remodeling through mediating the ...
2023年5月1日 · Our research demonstrates that polarization homeostasis of AMs mediated by PPARγ has the protective effect in airway remodeling, and may be a novel therapeutic target …
Artesunate ameliorates cigarette smoke-induced airway …
Increasing evidence has revealed that PPAR-γ agonists can inhibit the proliferation of human airway smooth muscle cells, and reduce inflammatory cell infiltration and airway remodelling …
Lipid metabolism in chronic obstructive pulmonary disease
Recent studies suggest that alterations in major lipid metabolic pathways contribute to pathogenesis of lung diseases, including chronic obstructive pulmonary disease (COPD). …
PPAR-γ在COPD所致肺动脉高压患者中的表达变化 - 百度学术
背景与目的:慢性阻塞性肺疾病 (COPD)是一种具有气流受限特征的疾病,气流受限不完全可逆,呈进行性发展,主要累及肺脏,但也可引起全身 (或肺外)的不良效应.肺动脉高压是COPD病情加重,预 …
PPAR-γ和MMP-9对COPD病人气道杯状细胞增生和MUC5AC表达 …
摘要 目的探讨气道中过氧化物酶体增殖物激活受体-γ(ppar-γ)和基质金属蛋白酶-9(mmp-9)对气道杯状细胞增生及黏蛋白5ac(muc5ac)表达的影响。方法选取男性肺鳞癌手术病人40例,根据肺功能 …
PPAR-γ 的上调参与淫羊藿苷对香烟烟雾引起的炎症的治疗作 …
采用western blotting、细胞免疫荧光和Real-time PCR检测PPARγ表达和NF-κB通路相关指标。构建 PPARγ 敲低或 T0070907 处理的 Beas-2B 细胞以进一步研究 ICA 和 PPARγ 对 NF-κB 的 …
The effect of peroxisome proliferator-activated receptor-γ ligands …
The anti-inflammatory potential of the PPAR-γ ligands rosiglitazone and pioglitazone were investigated using in vitro alveolar macrophage models and in vivo animal models relevant to …