The role of Peroxisome Proliferator-Activated Receptor-γ (PPARγ) in alveolar macrophages(AMs) polarization homeostasis is closely associated with airway remodeling in COPD, but the definite mechanism remains unclear. In this study, elevated percentage of M1-type AMs and the expression of functionall …

2024年4月20日 · Background: Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) represents a complex condition characterized by shared clinical and pathophysiological features of asthma and COPD in older individuals. However, the …

Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear hormone receptor with antioxidant effects. PPARγ activation has demonstrated protective effects against cigarette smoke-induced oxidative stress and inflammation. Molecular mechanisms for PPARγ's antioxidant function likewise remain to be elucidated.

2023年5月1日 · Our research demonstrates that polarization homeostasis of AMs mediated by PPARγ has the protective effect in airway remodeling, and may be a novel therapeutic target for the intervention and treatment of airway remodeling in COPD. 1. Introduction.

Increasing evidence has revealed that PPAR-γ agonists can inhibit the proliferation of human airway smooth muscle cells, and reduce inflammatory cell infiltration and airway remodelling by activating PPAR-γ in the context of COPD [7–9].

Recent studies suggest that alterations in major lipid metabolic pathways contribute to pathogenesis of lung diseases, including chronic obstructive pulmonary disease (COPD). These changes allow lung tissue to meet the energy needs and trigger anabolic pathways that initiate the synthesis of active molecules directly involved in the inflammation.

背景与目的:慢性阻塞性肺疾病 (COPD)是一种具有气流受限特征的疾病,气流受限不完全可逆,呈进行性发展,主要累及肺脏,但也可引起全身 (或肺外)的不良效应.肺动脉高压是COPD病情加重,预后不良的信号.为了更好地控制气道炎症,临床需要一种替代的治疗药物.过氧化物酶体增殖物激活受体-γ (PPAR-γ)是一种配体激活的核转录因子,属类固醇激素2型核受体超家族,对机体代谢过程起重要调节作用.近年来荧光免疫等方法发现,炎症细胞,气道上皮,支气管黏膜下层,气道及血管平滑肌细胞 …

摘要 目的探讨气道中过氧化物酶体增殖物激活受体-γ(ppar-γ)和基质金属蛋白酶-9(mmp-9)对气道杯状细胞增生及黏蛋白5ac(muc5ac)表达的影响。方法选取男性肺鳞癌手术病人40例,根据肺功能分为copd组和正常对...

采用western blotting、细胞免疫荧光和Real-time PCR检测PPARγ表达和NF-κB通路相关指标。构建 PPARγ 敲低或 T0070907 处理的 Beas-2B 细胞以进一步研究 ICA 和 PPARγ 对 NF-κB 的抑制之间的关系。CS暴露6个月建立COPD模型，胃灌注ICA（40 mg/kg）。

The anti-inflammatory potential of the PPAR-γ ligands rosiglitazone and pioglitazone were investigated using in vitro alveolar macrophage models and in vivo animal models relevant to chronic obstructive pulmonary disease (COPD). PPAR-γ protein and gene expression in COPD alveolar macrophages was compared with control smokers and never-smokers.