2005年3月25日 · In the present study, we demonstrated that COX-2 inhibits genotoxic stress-induced apoptosis by using an adenoviral COX-2 overexpression system. In addition, we …

2005年3月25日 · We showed that COX-2 is a downstream target gene of p53, whose expression is induced by p53 activation of the Ras/Raf/MAPK pathway. We also demonstrated that COX …

2004年12月20日 · Here we report that the tumor suppressor p53 upregulates COX-2 expression and that COX-2 can in turn inhibit p53-dependent transcription. Additionally, a COX-2-selective …

2002年11月1日 · Together, these results demonstrate that Cox-2 is induced by p53-mediated activation of the Ras/Raf/ERK cascade, counteracting p53-mediated apoptosis. This anti …

2021年5月10日 · We found that COX-2 inhibits the pro-senescent function of p53 under oncogenic RAS activation, by which it prevents oncogene-induced senescence (OIS) and …

2009年8月1日 · The p53-interacting region was critical for COX-2-mediated inhibition of p53 DNA-binding and transcriptional activity as well as p53- and genotoxic stress-induced apoptosis. In …

COX-2在多种肿瘤组织中过量表达,COX-2活性和前列腺素合成的增加促进细胞增殖、血管新生、肿瘤细胞浸润及抑制细胞凋亡.许多应激和前炎症信号,如氧自由基和DNA损伤剂,可诱导COX-2 …

2002年11月1日 · Through expression array analysis, we identified cyclooxygenase 2 (Cox-2), whose expression was inducible by wild-type p53 and DNA damage. We also found that p53 …

The association of COX-2 and p53 with various anti-oxidant enzymes showed a significantly positive correlation between COX-2 expression and catalase activity and an inverse …

2022年2月27日 · COX-2 can induce proliferation and angiogenesis via p53, p27 and vascular endothelial growth factor and also inhibit apoptosis by inducing the antiapoptotic factor Bcl-2, …