2023年11月1日 · At some point, high-quality polymer silica gel (of high-performance liquid chromatography [HPLC] grade), and then controlled pore glass (CPG) became the first widely used attractive supports for effective deoxyoligonucleotide solid-phase synthesis because of their ability to solve swelling issues observed in polymer (resin-type) supports.

2023年3月27日 · Given the various oligonucleotide therapeutic approaches and nucleotide modifications available, choosing the right solid support is essential for the synthesis of therapeutic-grade oligos. Read on for the basics on controlled pore glass (CPG) solid supports and to understand how to select the right support for your specific application.

艾美捷Lumiprobe Universal CPG type II, 1000A 是一种通用支持物，用于固定核苷以合成寡核苷酸并在去封闭过程中提高 3' 末端寡核苷酸的去磷酸化速率。 对于从载体上的切割和寡核苷酸脱保护无水氨气相，可以在…

Universal CPG solid support column for oligonucleotide synthesis. 'DMT-off' - no loss of yield through linker cleaving during the initial detritylation step, and no custom detritylation protocol required. 500 Å loads up to 85 µmol/g. 1000 Å loads up to 55 µmol/g. Available in different synthesis scales and column formats.

LGC’s CPG solid supports are available in a variety of pore sizes and functionalised nucleoside loadings. Six pore sizes are offered from 500 Å to 3000 Å to enable the synthesis of oligonucleotides for nearly any application. The pore size you’ll require depends on the length, complexity and application of the oligonucleotide.

In this review, the main focus is on supports for oligodeoxyribonucleotide and oligoribonu-cleotide synthesis. The synthetic strategies are often similar, particularly when synthetic li-braries are prepared.

Non-nucleosidic controlled pore glass (CPG) support with universal linkers for the solid phase oligonucleotide automated synthesis of the sequence with any nucleoside at 3'-terminus. MGB CPG 1000 用于合成含有二氢吡咯并吲哚三肽的寡核苷酸，用于与DNA 小沟结合。 这种通用支持物旨在用于寡核苷酸的自动合成，以加速解封闭过程中的去磷酸化过程。 对于多达 120 个碱基的寡核苷酸合成，建议使用 1000 Å 的孔径。

For DNA and RNA synthesis we supply 3’solid-phase CPG supports optimized for DNA and RNA synthesis in bulk or in pre-packed columns. Standard columns: manufactured for use on DNA synthesizers that use luer-to-luer columns. Supercolumns™: have an upper pipette fitting and a lower luer fitting.

There are several different types of CPG solid supports available, each with its own unique characteristics and properties. For example, some CPG supports are designed to have a high binding capacity for nucleotides, while others are optimized for high yields and purity of synthesized oligonucleotides.

BOC Sciences provides high-quality controlled pore glass (CPG) to ensure efficient and accurate synthesis of oligonucleotides. CPG is a rigid derivatized microporous glass ball made of silica. It is compatible with any solvent and is relatively stable to corrosive solvents and high temperature and high pressure.