The complement receptor 1 (CR1) gene encodes a transmembrane glycoprotein that functions in the innate immune system. CR1 is expressed on blood cells and microglia. As a receptor for …

2018年12月4日 · The CR1 gene sequence has exons 4 through 20 flanked by LoxP sites and exons 13 through 20 flanked by FRT sites. When these mutant mice are bred to mice that …

2023年10月4日 · Variations in complement receptor 1 (CR1) have been associated with an increased risk for AD (Almeida et al., 2018) and with effects on imaging biomarkers of AD (Zhu …

Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes. Arch Neurol. 2010 Dec;67(12):1473-84. PubMed. Bettens …

2015年11月13日 · Several SNPs near the complement receptor 1 (CR1) gene also associate with late-onset AD (see Jul 2009 conference news). The receptor plays a role in the innate immune …

2010年3月26日 · Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol Cell Biol. 2000 Jun;20(11):4106-14. …

2011年3月25日 · The complement receptor gene CR1 is an AD risk gene, currently occupying place 6 on the AlzGene Top Results ranking. “That is very novel and interesting, and has …

The innate immune system is where CR1 fits in, too. This gene encodes the receptor for proteins of the classical complement pathway, such as C3b/C4b, which mediates clearance of antigen …

2025年3月6日 · ApoE4 Gene May Be Risk Factor in Only a Subset of Cases. Add To My AlzForum; 21 Feb 1997. A new study reports that the ApoE4 gene, previously reported to be …

2014年9月5日 · Sometimes the eQTL showed up within the gene it regulated. For example, a risk SNP for Alzheimer’s disease that lies within the complement receptor 1 gene on chromosome …