2024年12月24日 · CR1L (Complement C3b/C4b Receptor 1 Like) is a Protein Coding gene. Diseases associated with CR1L include Alzheimer's Disease 1 and Nephronophthisis 1. An important paralog of this gene is CR1. Interacts with iC4 (methylamine-treated C4) but not for iC3 (methylamine-treated C3). Belongs to the receptors of complement activation (RCA) family.

Complement receptor type 1 (CR1) also known as C3b/C4b receptor or CD35 (cluster of differentiation 35) is a protein that in humans is encoded by the CR1 gene. [3][4] This gene is a member of the regulators of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1.

2023年10月13日 · This review will focus on the extracellular domain of CR1 and detail how its highly duplicated domains work both separately and together to mediate binding to its main ligands C3b and C4b, and to inhibit the classical, lectin, and alternative pathways of the complement cascade via the mechanisms of decay acceleration activity (DAA) and co ...

2023年10月13日 · This review will focus on the extracellular domain of CR1 and detail how its highly duplicated domains work both separately and together to mediate binding to its main ligands C3b and C4b, and to inhibit the classical, lectin, and alternative pathways of the complement cascade via the mechanisms of decay acceleration activity (DAA) and co ...

2024年12月24日 · CR1 (Complement C3b/C4b Receptor 1 (Knops Blood Group)) is a Protein Coding gene. Diseases associated with CR1 include Malaria and Follicular Dendritic Cell Sarcoma. Among its related pathways are Complement cascade …

CR1 is the most versatile inhibitor of both classical and alternative pathway C3 and C5 convertases due to its decay-accelerating activity and co-factor activity for C3b/C4b cleavage. Moreover, CR1 plays a major role in immune complex clearance due to …

The C3b/C4b receptor (CR1; 120620) is important in immune complex processing. On phagocytic cells it promotes the adherence and sometimes the endocytosis of C3b- and C4b-coated particles. CR1 is composed largely of a tandemly repeated motif of approximately 60 amino acids, the short consensus repeat (SCR).

CR1 is a multiple modular protein that binds C3b (120700)/C4b (120820)-opsonized foreign antigens. By doing so, CR1 mediates the immune adherence phenomenon, a fundamental event for destroying microbes and initiating an immunologic response (Smith et al., 2002).

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2018年1月11日 · Human complement receptor 1 (CR1) plays a role in the clearance of complement opsonized molecules and may facilitate the entry of pathogens into host cells....