2024年7月1日 · We identified LHR-ABCC, a soluble CR1 variant containing a duplicated C3b-binding C-terminal LHR-C domain that exhibited significantly enhanced alternative pathway inhibitory activity in vitro compared to CSL040.

2023年10月13日 · This review will focus on the extracellular domain of CR1 and detail how its highly duplicated domains work both separately and together to mediate binding to its main ligands C3b and C4b, and to inhibit the classical, lectin, and alternative pathways of the complement cascade via the mechanisms of decay acceleration activity (DAA) and co ...

sCR1-sLe(x) has been proposed to be useful in ischemia-reperfusion injury, thermal injury and immune complex mediated injury (Asghar and Pasch, 2000). Its efficacy in preventing lung ischemia-reperfusion injury as well as stroke reperfusion injury has been studied extensively (Stammberger et al., 2000, Ducruet et al., 2007).

2023年10月13日 · This review will focus on the extracellular domain of CR1 and detail how its highly duplicated domains work both separately and together to mediate binding to its main ligands C3b and C4b, and to inhibit the classical, lectin, and alternative pathways of the complement cascade via the mechanisms of decay acceleration activity (DAA) and co ...

2018年1月11日 · Human complement receptor 1 (CR1) plays a role in the clearance of complement opsonized molecules and may facilitate the entry of pathogens into host cells....

Human complement receptor 1 (CR1) is a membrane-bound regulator of complement that has been the subject of recent attempts to generate soluble therapeutic compounds comprising different fragments of its extracellular domain. This review will focus ...

CR1 is an excellent model to study structure-function relationships because its functions are mediated by two distinct but highly homologous sites, each composed of three CCPs. CR1 derivatives carrying just one active site were used to define critical sequences/amino acids.

CR1 is a multiple modular protein that binds C3b (120700)/C4b (120820)-opsonized foreign antigens. By doing so, CR1 mediates the immune adherence phenomenon, a fundamental event for destroying microbes and initiating an immunologic response (Smith et al., 2002).

本综述总结了b细胞表达的补体受体与这些配体相互作用的作用，即cr1（cd35）、cr2（cd21）、cr3（cd11b/cd18）和cr4（cd11c/cd18）在健康和疾病中的作用。 虽然我们专注于人类 B 淋巴细胞，但我们也旨在提醒人们注意人类和小鼠系统之间的重要差异。

CR1 is a membrane receptor that controls complement activation by accelerating decay of the C3 convertase and acting as a co‐factor for factor I (FI)‐mediated conversion of C3b to iC3b, the ligand for the phagocytosis receptor complement receptor 3 (CR3; CD11b/CD18) (Jensen et …