2024年8月30日 · Our study provides a single-cell full-length transcriptomic atlas of colorectal cancer (CRC), identifying tumor-specific/-associated RNA isoforms and highlighting their potential in generating shared neoantigens across CRC patients. This may facilitate the development of universal neoantigen-based cancer vaccines for CRC.

Colorectal cancer is an aggressive tumor with high global prevalence, and interestingly enhanced CPE expression has been documented in both colorectal cancer (CRC) cell lines and patient tumor samples [10]. Using two CRC cell lines, it was shown that overexpression of full-length CPE enhances the proliferation and colony forming ability of ...

2024年7月8日 · Expanding the efficacy of immune checkpoint blockade (ICB) in colorectal cancer (CRC) presses for a comprehensive understanding of treatment responsiveness. Here, we analyze multiple sequential single-cell samples from 22 patients undergoing PD-1 blockade to map the evolution of local and systemic immunity of CRC patients.

2017年7月6日 · This study expands the view of CRC cell lines as accurate molecular models of primary carcinomas, and we present integrated multi-level molecular data of 34 widely used cell lines in easily accessible formats, providing a resource for preclinical studies in CRC.

2015年4月30日 · Here we describe the mutational and gene expression analyses of 151 colorectal cancer (CRC) cell lines. We find that the whole spectrum of CRC molecular and transcriptional subtypes, previously...

2023年1月3日 · 本研究通过构建CRC类人小鼠转移复发模型， 揭示了一群EMP1高表达的HRC细胞对于转移定植至关重要，而LGR5+干细胞样肿瘤细胞对于CRC转移后的生长起关键作用。 这些研究成果也表明特异性靶向HRC能够有助于减少转移性复发CRC。 转载须知 【原创文章】BioArt原创文章，欢迎个人转发分享，未经允许禁止转载，所刊登的所有作品的著作权均为BioArt所 …

2024年7月8日 · Expanding the efficacy of immune checkpoint blockade (ICB) in colorectal cancer (CRC) presses for a comprehensive understanding of treatment responsiveness. Here, we analyze multiple sequential single-cell samples from 22 patients undergoing PD-1 blockade to map the evolution of local and systemic immunity of CRC patients.

2023年12月7日 · A spatial multi-omic atlas uncovers the diverse genetic and transcriptomic landscape of human colorectal lesions along progression to malignancy, highlighting the relationship between CRC evolution and tumor cytotoxic immunity.

We have developed a deep learning–based method to measure the similarity between CRC tumors and disease models such as cancer cell lines. Our method efficiently leverages multiomics data sets containing copy number alterations, gene expression, and point mutations and learns latent factors that describe data in lower dimensions.

2025年3月3日 · Colorectal cancer (CRC) progresses through a series of stages, marked by the accumulation of mutations in colonic epithelial cells [].The cancer cells generally become more heterogeneous, which in ...