热休克蛋白90（HSP90）是细胞内一种普遍存在的、十分保守的以及有高度活性的蛋白质，它在肿瘤细胞内的含量要比正常细胞多。 作为一种 分子伴侣，HSP90协助不同种类的癌蛋白（即HSP90的服务蛋白）进行折叠并使之变得稳定、成熟，而HSP90的服务蛋白中拥有大量的诸如激酶和转录因子等信号转导分子，这些分子对于肿瘤的形成和生长发挥着重要作用。 HSP90在不同的癌症中过度表达，它们被认为是结直肠癌（CRC）中的致癌基因。 这些伴侣有选择性地稳定和 …

Heat shock proteins (HSP) have been found to be elevated in CRC patients and HSPB1, HSPA1A and HSPC1 has been shown to have some prognostic value. CRC, in common with all cancers, has important associated oncogene and tumor suppressor gene associations and we show how many of these interact directly with one or more of the HSP.

In this study, we aimed to assess the prognostic significance of the three main HSPs described in relation to CRC in the literature (HSP 27, 70, 110), evaluating the correlation of HSP expression with the survival of patients suffering from CRC, and to discover the eventual link of HSP status to traditional clinico-pathological variables like ...

Using Least Absolute Selection and Shrinkage Operator (LASSO) regression and univariate/multivariate Cox regression analyses, 12 HSP-related genes demonstrating significant associations with CRC survival were successfully identified and employed to formulate a predictive risk score model.

Here, we characterised the expression of two major HSP proteins (HSP27 and 72) by immunohistochemistry (IHC), the mutation status of TP53, KRAS and PIK3CA genes by direct sequencing and the activation status of AKT by IHC in a …

2021年10月24日 · In this review, we discuss the functional role of HSPs in CRC progression and highlight the significance of HSPs as diagnostic and prognostic biomarkers and emerging anti-CRC therapies that target HSPs in CRC.

2018年5月20日 · Microbial involvement in colorectal cancer (CRC) is now well established. Short Chain Fatty Acids (SCFA) is the main products of anaerobic microbial fermentation in the large intestine and affects colonic health. SCFA mainly produced as microbial metabolites, acetate, propionate, and butyrate acids.

Heat shock protein 27 (Hsp27) is one of the most studied members of Hsp family. It has attracted particular attention in CRC pathogenesis, since it is involved in fundamental cell functions for cell survival. Evidence show that Hsp27 plays important roles in CRC progression and metastasis.

2016年4月22日 · In colon cancers, HSP110 is abnormally abundant. We have recently showed that colorectal cancer (CRC) patients with microsatellite instability (MSI) had an improved response to chemotherapy because they harbor an HSP110 inactivating mutation (HSP110DE9).

2018年8月1日 · In the present study, we conducted a genome-scale co-expression analysis to reconstruct the HSP in colorectal cancer (CRC). Five key modules were detected through network clustering, and a detailed discussion of two modules containing respectively 18 and 13 over and down-regulated members of HSP was provided.