CRS usually occurs between 1 and 14 days after the CAR T-cell infusion and can last up to ten days. Delayed onset CRS can occur but rarely presents beyond this period. The severity of …

CRS is an acute systemic inflammatory response, characterised by fever and in severe events can lead to multiple organ dysfunction. Severity of CRS ranges from mild to life-threatening, …

2017年11月27日 · Grade 1: fever with or without constitutional symptoms. Grade 2: hypotension responding to fluids; hypoxia responding to <40% O 2. Grade 3: hypotension managed with …

Organ toxicities associated with CRS may be graded according to CTCAE v5.0 but they do not influence CRS grading. * Fever is defined as temperature ≥38°C not attributable to any other …

CRS is an exaggerated response of the innate immune system, which activates the adaptive immune system causing a further activation of innate immune cells and release of more …

CRS is a rare but serious condition that represents a supraphysiologic response to immunotherapy with a resultant overproduction of cytokines from immune effector cells. High …

Cytokine-release syndrome (CRS), the most commonly observed toxicity, can range in severity from low-grade constitutional symptoms to a high-grade syndrome associated with life …

Excessive and rapid release of cytokines into the blood stream can result in cytokine release syndrome (CRS). CRS is an acute systemic inflammatory response, characterised by fever …

2022年11月15日 · CAR T cell therapy can be complicated by cytokine release syndrome (CRS), a syndrome characterized by systemic inflammatory response, in which interleukin (IL) -6 plays …

2019年5月16日 · Fever ≥38°C as an early sign of CRS occurred with a median of 2 ± 0.3 days (range, 0-4 days) after infusion of CAR T cells in low-grade neurotoxicity patients. In this …