2014年12月6日 · Central nervous system (CNS) involvement is considered rare in adults with acute myeloid leukemia (AML). Therefore the cerebrospinal fluid (CSF) is typically examined only in patients with CNS symptoms.

AML CNS involvement was defined as unequivocal morphologic or immunophenotypic evidence of leukemic blasts in the CSF, or, in symptomatic patients by abnormal findings on computed tomography (CT) or magnetic resonance imaging (MRI).

Acute myeloid leukemia (AML) is a rare and aggressive malignancy that can present with a broad range of clinical manifestations. Central nervous system (CNS) involvement is rarely documented and may alter the treatment course and overall prognosis.

Improvements in systemic therapy in the treatment of acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) have improved patient outcomes and reduced the incidence of CNS relapse. However, management of patients with CNS disease ...

After a first study showed that GM-CSF following chemotherapy effectively accelerated neutrophil recovery and reduced early mortality in high risk patients with AML, a second study was begun in which GM-CSF was applied preceding chemotherapy and continuing until …

2022年8月1日 · In this article, we take a closer look at how acute myeloid leukemia in your spinal fluid and CNS affects AML symptoms, treatment, and outlook. How often does acute myeloid …

一研究团队回顾性分析了G-CSF对 526 例基于蒽环类药物的诱导化疗治疗的非M3急性AML患者结局的影响，并分析粒细胞集落刺激因子（G-CSF）对急性髓系白血病（AML）患者结局的影响。

在接受缓解诱导治疗的成人AML患者中，G-CSF初级预防与感染相关死亡率无关；而G-CSF显著缩短了中性粒细胞减少的持续时间。 此外，G-CSF的初级预防并不影响疾病进展/复发、OS或不良事件，如肌肉骨骼疼痛。

靶向基因的小鼠模型研究显示，MLKL可通过控制白血病细胞的膜透化促进G-CSF（粒细胞集落刺激因子）的释放。 AML患者中MLKL的表达显著降低. 研究人员发现，Mlk1-/-造血 干细胞 和祖细胞释放的G-CSF减少，但同时保留了细胞的CSF3（G-CSF）mRNA 表达、G-CSF蛋白翻译和G-CSF受体信号转导的能力。 MLKL的表达水平与AML中的炎症反应特征相关. 进一步的研究显示，MLKL与早期核内体相关，并能够通过介导质膜孔的形成来调控G-CSF从细胞内释放， …

2003年8月21日 · We conducted a randomized trial to determine whether G-CSF given only during the first two induction cycles with cytarabine plus idarubicin and cytarabine plus amsacrin improves disease-free...