2020年3月23日 · Using CRISPR DNA-fragment editing, in conjunction with chromosome conformation capture, we find that CTCF sites, if located between enhancers and promoters in …

2012年11月6日 · However, here, we discovered a role of CTCF for promoter activation in the clustered Pcdh genes. Our results reveal that the enhancer-bound CTCF recruits the cohesin …

2017年10月27日 · Here, we report four crystal structures of human CTCF in complex with CBSs of the protocadherin (Pcdh) clusters. We show that directional CTCF binding to cognate CBSs …

2024年1月23日 · ZNF143 deletion significantly slows down the cell proliferation (Figure S3C) but does not affect the CTCF enrichments in the PCDH clusters (Figures 3A–3C). However, the …

CTCF (CCCTC-binding factor) instructs 3D genome folding by anchoring or forestalling cohesin loop extrusion, but the exact mechanism remains obscure. Here, using clustered …

2023年12月7日 · Here, using Pcdh and HOXD as model genes, we find that outward-oriented CBS elements within clustered CTCF boundaries are crucial for intra-TAD promoter-enhancer …

本文确定了Pcdh 下游调控区域的所有CBS位点，并发现了CTCF 蛋白在基因组范围内与启动子-增强子相互作用的关系。 因此推测在CTCF 蛋白作用下增强

Specifically, we propose that the regulation of cohesin extrusion trajectories—defined as cohesin processivity, density, and stalling at a CTCF boundary at the center of the locus—together with …

2012年8月30日 · These results demonstrated that CTCF is a global regulator of the clustered Pcdh family that is especially required for the stochastically expressed isoforms and indicated …

2012年12月18日 · The closely linked human protocadherin (Pcdh) α, β, and γ gene clusters encode 53 distinct protein isoforms, which are expressed in a combinatorial manner to …