2024年4月1日 · Welcome to the Blood & Marrow Transplant Clinical Trials Network (BMT CTN) Improving therapies. Saving lives.

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BMT CTN (Blood and Marrow Transplant Clinical Trials Network ) o Established in September 2001 and renewed in 2006, 2011, and 2017 (through 2024) o Funded through the National Heart Lung and Blood Institute (NHLBI) and the National Cancer Institute

The Blood and Marrow Transplant Clinical Trials Network (BMT CTN) conducts large, multi-institutional trials to improve outcomes of cellular therapies, such as hematopoietic cell transplantation (HCT), cellular vaccines, and chimeric antigen receptor T cells (CAR-T) for patients facing life-threatening disorders.

2021年12月2日 · In summary, the BMT CTN 1301 trial demonstrated similar but not better CRFS after two CNI-free GVHD prophylaxis strategies to standard Tac and MTX after HLA-matched transplantation with myeloablative conditioning. CD34 selection was associated with significant reduction in cGVHD, although this benefit was offset by an excess of TRM.

2021年12月2日 · Randomized Phase III BMT CTN Trial of Calcineurin Inhibitor–Free Chronic Graft-Versus-Host Disease Interventions in Myeloablative Hematopoietic Cell Transplantation for Hematologic Malignancies. JCO 40, 356-368 (2022).

2016年3月28日 · The BMT CTN was established in October of 2001 to conduct large, multi-institutional clinical trials addressing important issues in hematopoietic stem cell transplantation (HCT). The participating BMT CTN investigators collaborate to implement and complete well-designed clinical trials of high scientific merit, offering trial participation to ...

2023年11月21日 · We present the results of a Blood and Marrow Transplant Clinical Trials Network (BMT CTN) 1507, multi-center single-arm, phase-II, prospective clinical trial (clinicaltrials.gov #NCT03263559) of haploidentical-BMT with PTCy to estimate EFS at 2-years in adults with severe SCD.

2020年5月25日 · Long-term follow-up of BMT CTN 0702 (STaMINA) of postautologous hematopoietic cell transplantation (autoHCT) strategies in the upfront treatment of multiple myeloma (MM). Authors : Parameswaran Hari , Marcelo C. Pasquini , Edward Allen Stadtmauer , Raphael Fraser , Mingwei Fei , Steven Michael Devine , Yvonne Adeduni Efebera , …

The BMT CTN has 19 Core Clinical Centers. Each Core Center holds a cooperative agreement with the NHLBI to participate in the BMT CTN. These centers were chosen based on the scientific merit of their grant applications to the NIH, as well as evidence of their ability to collaborate in carrying out the Network mission of developing and ...