Cullin 1, also known as CUL1, is a human protein and gene from cullin family. This protein plays an important role in protein degradation and protein ubiquitination.

2024年12月24日 · CUL1 (Cullin 1) is a Protein Coding gene. Diseases associated with CUL1 include Vaccinia and Uv-Sensitive Syndrome. Among its related pathways are Regulation of …

CUL1 也被称为卡林，是人类的从卡林家族发现的蛋白质。 这个蛋白在 蛋白质降解 和蛋白质泛素化中起着重要的作用。 这是SCF（SKP1 CUL1- F-box蛋白的）E3 泛素连接酶 复合物的一个 …

The SKP1‐CUL1‐F‐box (SCF) E3 ubiquitin ligase, a member of the Cullin‐RING E3 ubiquitin ligase (CRL) family, plays a crucial role in mediating protein ubiquitination and subsequent …

Predicted to enable ubiquitin protein Ligase binding activity and ubiquitin-protein transferase activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic …

2002年4月18日 · Cul1 serves as a rigid scaffold that organizes the Skp1–F box Skp2 and Rbx1 subunits, holding them over 100 Å apart. The structure suggests that Cul1 may contribute to …

2020年8月18日 · When analyzing chromatin affinity of individual cullins, we discovered that CUL1 preferentially associated with active promoter sequences and co-localized with 23% of all DNA …

2024年12月10日 · Title: Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation. Abnormal Cullin1 neddylation-mediated …

In this paper, we report that the highly conserved cullin C-terminal sequence and binding with ROC1 are both required for efficient nuclear accumulation of cullin. Blocking of CUL1 nuclear …

Here, we discover that Cullin1 (CUL1), a key component of the Skp1-Cullin1-F-box E3 ligase, plays a critical role in controlling the NLRP3 inflammasome. CUL1 represses inflammasome …