Chemokine (C-X-C motif) ligand 14 (CXCL14) is a small cytokine belonging to the CXC chemokine family that is also known as BRAK (for breast and kidney-expressed chemokine). [1] .

CXCL14是趋化因子CXC家族的一个新成员，最早从人类乳腺和肾脏组织中分离克隆而来。 CXCL14参与调控体内许多生物学过程，如炎症免疫反应，肿瘤相关的血管生成，宿主对肿瘤特异免疫的激活以及肿瘤生长的自分泌调节等…

2024年12月24日 · CXCL14 (C-X-C Motif Chemokine Ligand 14) is a Protein Coding gene. Diseases associated with CXCL14 include Cervical Squamous Cell Carcinoma and Squamous Cell Carcinoma, Head And Neck. Among its related pathways are MIF Mediated Glucocorticoid Regulation and ERK Signaling.

CXCL14 displays chemotactic activity for monocytes but not for B and T cells. CXCL14 is involved in cancer, immune responses, and epithelial cell proliferation and migration.

2016年1月5日 · CXCL14, a relatively novel chemokine, is a non-ELR (glutamic acid-leucine-arginine) chemokine with a broad spectrum of biological activities. CXCL14 mainly contributes to the regulation of immune cell migration, also executes antimicrobial immunity. The identity of the receptor for CXCL14 still rema …

Integrative analyses of scRNA-seq and scATAC-seq reveal CXCL14 as a key regulator of lymph node metastasis in breast cancer. Upregulated CXCL14 is associated with poor survival outcomes and promotes ovarian cancer cells proliferation.

2024年1月6日 · Patients with idiopathic pulmonary fibrosis show a strongly upregulated expression of chemokine CXCL14, whose target is still unknown. Screening of CXCL14 in a panel of human G protein-coupled...

体内试验中肿瘤细胞表达的CXCL14会引起未成熟的树突状细胞 (DC)向肿瘤聚集，在体外实验中，CXCL14能够促使DC的活化。 肿瘤细胞通过下调CXCL14的表达减少DC的聚集从而形成了免疫逃逸 10。

2024年1月29日 · Therefore, we hypothesized that CXCL14 promotes the development of neurons in the somatic layer of the pyramidal cells of mice cortex on embryonic day 14.5. In order to further explore its mechanism, CXCR4 and CXCR7 were suggested as receptors by Membrane-Anchored Ligand and Receptor Yeast Two-Hybrid technology.

CXCL14 plays important roles in immune surveillance, inflammation and tumor development by regulating cell migration [4]. Previous studies showed that CXCL14 is expressed at high levels in fetal, adult and adult mouse brain tissues, including the cortex, hippocampus and cerebellum.