Chemokine (C-X-C motif) ligand 9 (CXCL9) is a small cytokine belonging to the CXC chemokine family that is also known as monokine induced by gamma interferon (MIG). The CXCL9 is one of the chemokine which plays role to induce chemotaxis, promote differentiation and multiplication of leukocytes, and cause tissue extravasation. [5]

2024年12月24日 · CXCL9 (C-X-C Motif Chemokine Ligand 9) is a Protein Coding gene. Diseases associated with CXCL9 include Proliferative Glomerulonephritis and Paracoccidioidomycosis. Among its related pathways are MIF Mediated Glucocorticoid Regulation …

CXCL9（英語： Chemokine (C-X-C motif) ligand 9 ）是一小分子的细胞因子属于CXC趋化因子家族，又被称作“干扰素伽玛诱导的单核细胞因子”（Monokine induced by gamma interferon, MIG） [5] 。CXCL9是T细胞趋化因子 [5] 。干扰素伽玛诱导CXCL9的表达。

CXCL9, also known as monokine induced by gamma interferon (MIG), is located on human chromosome 4, and is induced by IFN-γ but not by IFN-α/β. CXCL10 and CXCL11 are also located on human chromosome 4. CXCL9 predominantly mediates lymphocytic infiltration to the focal sites and suppresses tumor growth.

cxcl9 是趋化因子受体 cxcr3 的配体之一，可介导淋巴细胞浸润到病灶部位并抑制肿瘤生长。 CXCL9 吸引 CXCR3-(CXCR3-A 和 CXCR3-B) T 淋巴细胞，参与多种生理疾病在其起始和维持期间的发病机制。

2023年8月16日 · 他们的最新研究“CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers”已于著名期刊《Science》上发表。作者发现，由 CXCL9 和 SPP1 这两个基因的表达所定义的巨噬细胞极性的变化是肿瘤微环境的一个简单而关键 …

CXCL9 expression in lesional macrophages implicates the skin as the source of circulating cytokines. CXCL9 is a promising biomarker of disease activity in morphea. results support the notion that CXCL9 and CXCL10 exert tumour-suppressive …

趋化因子配体 9（Chemokine Ligand 9，CXCL9）是一种属于趋化因子家族的细胞因子，在免疫细胞的招募、迁移和免疫应答调节等过程中发挥关键作用。 CXCL9 是一种小分子分泌蛋白，通常由约 100 个氨基酸组成。 其结构包含多个 β - 折叠片层，这些 β - 折叠通过二硫键相互连接，形成一个相对稳定的三级结构。 这种结构使得 CXCL9 能够在细胞外环境中保持活性，并有效地与受体结合。 增强细胞免疫反应：CXCL9 在细胞免疫反应中起到增强作用。 它不仅能够招募免疫细 …

2023年3月26日 · tme中的cxcl9、10、11/cxcr3信号通路主要促进cxcr3激活的免疫细胞向肿瘤部位的趋化运动，以获得抗肿瘤免疫。cxcl9和cxcl10是许多免疫反应的关键组成部分，通过与cxcr3结合并诱导其进入炎症部位来激活nk和th1细胞。

The CXCL9, -10, -11/CXCR3 axis regulates immune cell migration, differentiation, and activation, leading to tumor suppression (paracrine axis). However, there are some reports that show involvements of this axis in tumor growth and metastasis (autocrine axis).