2024年12月24日 · CXCR2 (C-X-C Motif Chemokine Receptor 2) is a Protein Coding gene. Diseases associated with CXCR2 include Whim Syndrome 2 and Autosomal Recessive Severe Congenital Neutropenia Due To Cxcr2 Deficiency. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling.

One of the 20 chemokine receptors identified to date is CXCR2, a G-protein-coupled receptor (GPCR) whose most known ligands are CXCL8 (IL-8) and CXCL1 (GRO-α). In this article we present a comprehensive review of literature concerning the role of CXCR2 in cancer.

2023年10月21日 · CXCR2 plays diverse and novel roles in cancer, physiology, and viral infection (COVID-19) beyond its widely accepted role in bacterial infections. The pro- or antitumoral action of CXCR2 remains under debate because this varies …

2020年7月1日 · Here we present the cryo-electron microscopy structures of interleukin-8 (IL-8, also known as CXCL8)-activated human CXC chemokine receptor 2 (CXCR2) in complex with G i protein, along with a...

CXCR2 is key stimulant of immune cell migration and recruitment, especially of neutrophils. Alleviating excessive neutrophil accumulation and infiltration could prevent prolonged tissue damage in inflammatory disorders. This review focuses on recent ...

Chemokines can have both homeostatic and in flammatory functions [1,2]. Among them, the chemokine receptor CXCR2 is expressed in diverse cell types predominantly neutrophils, and to a lesser extent in endothelial cells, macrophages, oligodendrocytes, neurons, neural crest-derived cells, and some cancer cells.

For this reason, this review describes the significance of the ligands for receptors CXCR1, CXCR2, CXCR3, CXCR5, and CXCR6 in AML. The focus is on clinical aspects as well as molecular cancer processes in AML.

Recent findings have modified our understanding of the roles of chemokine receptor CXCR2 and its ligands in cancer, inflammation, and immunity. Studies in Cxcr2 tissue-specific knockout mice show that this receptor is involved in, among other …

2012年8月24日 · This review gives an overview of the structure of CXCR2 and the signaling pathways that are activated following CXCR2 stimulation. We discuss in detail the role of this chemokine receptor in different disease models including acute lung injury, COPD, sepsis, and ischemia-reperfusion-injury.

9 CXCR2 Chemokine Receptor The CXCR2 chemokine receptor mediates chemotaxis of leukocytes and also regulates wound healing, angiogenesis, and inflammation. This GPCR possesses a C-terminal PDZ motif (STTL) that functions in both trafficking and signaling.