CXCR6是一种 G 蛋白偶联受体，具有七个跨膜结构域，属于 CXC 趋化因子受体家族。 重点： 1. CXCR6对于由 CD8+细胞毒性T细胞 (CTL)介导的持续肿瘤控制至关重要； 2. CXCR6优化CTL与传统DC的CCR7+ DC3状态的相互作用； 3. DC3s 将IL-15反式呈递到 TCF-1neg 效应子样CTLs以维持它们在TME中的存活； 4. DC3s密集地聚集在肿瘤基质的富含T细胞的血管周围壁龛中；

2022年10月12日 · CXCR6 is a receptor for the chemokine CXCL16, which exists as a membrane or soluble form. CXCR6 is a marker for resident memory T (T_RM) cells that plays a role in immunosurveillance through their interaction with epithelial cells.

2024年12月24日 · CXCR6 (C-X-C Motif Chemokine Receptor 6) is a Protein Coding gene. Diseases associated with CXCR6 include Type 1 Diabetes Mellitus 22 and Sarcoidosis 1. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling.

C-X-C chemokine receptor type 6 is a protein that in humans is encoded by the CXCR6 gene. [5] [6] [7] CXCR6 has also recently been designated CD186 (cluster of differentiation 186). CXCR6 has been identified as an entry coreceptor used by HIV-1 and SIV to enter target cells, in conjunction with CD4.

2021年8月19日 · Here, we show that the conversion of stem-like into effector-like CTLs involves a major chemotactic reprogramming that includes the upregulation of chemokine receptor CXCR6. This receptor positions effector-like CTLs in a discrete perivascular niche of the tumor stroma that is densely occupied by CCR7 + dendritic cells (DCs) expressing the ...

2021年9月13日 · 利用cxcr6敲除小鼠作者发现在肿瘤中效应性ctl和tcf-1+干细胞样ctl的累积和维持具有重要作用。全面检测cxcr6敲除小鼠肿瘤中各ctl亚群中ki67的表达水平，作者发现在tcf-1-neg ctl中ki67的表达量降低最为明显，异位表达bcl-2则能够明显恢复小鼠肿瘤水平至对照组水平。

CXCR6 (CD186)是一种 趋化因子受体，与其单独的配体CXC趋化因子配体16 (CXCL16)一起被克隆。 CXCR6基因定位于染色体3p21.31，有4个剪接变异体。 它属于CXC趋化因子受体家族，由CXC趋化因子受体1 (CXCR1)、CXC趋化因子受体2 (CXCR2)、CXC趋化因子受体3 (CXCR3)、CXC趋化因子受体4 (CXCR4)、CXC趋化因子受体5 (CXCR5)和CXC趋化因子受体6 (CXCR7)等6个成员组成。 一些研究表明，CXCR6的表达是T细胞分化的标志，也可能是某些疾病的生物 …

CXCR6 / CCL16 还控制驻留记忆 T 淋巴细胞定位到肺的不同隔室，并维持气道驻留记忆 T 淋巴细胞，这是抵御呼吸道病原体的重要第一道防线。 编码的蛋白质与 CD4 一起用作 HIV-1 和 SIV 进入靶细胞的进入辅助受体。 [RefSeq 提供，2020 年 8 月] The protein encoded by this gene is a G protein-coupled receptor with seven transmembrane domains that belongs to the CXC Chemokine Receptor family.

2022年8月1日 · We propose that CXCR6-based immunotherapy will play a significant role in autoimmune, nonalcoholic steatohepatitis (NASH), tumor, coronavirus disease 2019 (COVID-19) and even ageing-related inflammatory infliction.

2025年2月8日 · CXCR6 expression is down-regulated, independent of CCR5 or CD69 expression and of cytokine induction, by T cell activation signals that involve predominantly the Ca(2+)-dependent calcineurin pathway. CXCR6 was expressed more frequently on synovial T cells than in peripheral blood