Weighted gene co-expression network analysis reveals that CXCL10, IRF7 …
Furthermore, C-X-C motif chemokine ligand 10 (CXCL10), myxovirus (influenza virus) resistance 1 (MX1), signal transducer and activator of transcription 1 (STAT1), interferon regulatory factor 7 (IRF7) and radical S-adenosyl methionine domain containing 2 (RSAD2) were identified as the hub genes in the PPI and Venn diagram network, and verified ...
Induction of Cxcl10, Ifit1, Irf7 and IFNb1 are more
In addition, both IRF3 and IRF7 can induce IFIT expression independent of classic type I IFN signaling (42). As such, further study of the differences between the upper and lower airway are ...
Interferon regulatory factor 7 in inflammation, cancer and infection
Interferon regulatory factor 7 (IRF7), a member of the interferon regulatory factors (IRFs) family, is located downstream of the pattern recognition receptors (PRRs)-mediated signaling pathway and is essential for the production of type I interferon (IFN-I).
IRF7: activation, regulation, modification and function
2011年4月14日 · Interferon regulatory factor 7 (IRF7) was originally identified in the context of Epstein–Barr virus (EBV) infection, and has since emerged as the crucial regulator...
IRF-7 is the master regulator of type-I interferon-dependent …
2005年4月7日 · Using mice deficient in the Irf7 gene (Irf7-/- mice), we show that the transcription factor IRF-7 is essential for the induction of IFN-alpha/beta genes via the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway.
汉滩病毒通过TLR3/IRF7/NF-κB途径调控CXCL10的表达 - 百度学术
研究背景:汉滩病毒(hantaan virus,HTNV)是在我国引起肾综合征出血热(hemorrhagic fever with renal syndrome,HFRS)的主要病原体之一.HFRS是一种以发热,出血和急性肾功能损害为特征的急性传染病.全球每年HFRS发病人数达10万例,死亡率为2%~10%;90%以上病例发生在我国.HFRS的 …
IRF7: role and regulation in immunity and autoimmunity
2023年8月9日 · MicroRNAs regulate IRF7 expression by modulating mRNA stability. miR-223 and miR-155-5p enhance IRF7 expression by targeting FOXO3 (37, 38), miR-127 promotes IRF7 expression by inhibiting the signal-dependent turnover of the Bcl6 coregulator , miR-144 negatively regulates IRF7 activity by suppressing the TRAF6-IRF7 signaling axis , and miR29a ...
EMBO丨长期暴露于 TGFb1 以 IRF7 依赖性方式调节骨髓细胞炎症 …
为了证实 IRF7 在 M1 到 M2 转化中的新功能作用，作者使用小干扰 RNA (siRNA) 来沉默 BM-MΦ 离体中的 Irf7 表达（从而将 BM-MΦ 中的 Irf7 水平降低到与 小胶质细胞）并测试了其对促炎和抗炎基因表达的影响（图3F）。
CXCL10 - Wikipedia
C-X-C motif chemokine ligand 10 (CXCL10) also known as Interferon gamma-induced protein 10 (IP-10) or small-inducible cytokine B10 is an 8.7 kDa protein that in humans is encoded by the CXCL10 gene. [5] [6] C-X-C motif chemokine 10 is a small cytokine belonging to the CXC chemokine family.
IRF7: role and regulation in immunity and autoimmunity
2023年8月10日 · In this review, we provide a comprehensive overview on the current knowledge of the role of IRF7 in immunity and autoimmunity. We focus on the latest regulatory mechanisms of IRF7 in IFN-I, including signaling pathways, transcription, translation, and post-translational levels, the dimerization and nuclear translocation, and the role of IRF7 in ...