This article reviews the available published data regarding the presence and impact of genetic polymorphisms on CYP-dependent drug metabolism in dogs in the context of known human-dog CYP differences. Canine CYP1A2, which metabolizes phenacetin, caffeine, and theophylline, is the most widely studied polymorphic canine CYP.

有研究报道，依据偏经验数据整体而言，犬的CYP2D活性与人最相似，猴的CYP2C与人最接近，小鼠的CYP1A与人较接近，雄性大鼠的CYP3A活性最接近人。 但是基于目前对代谢酶种属差异的认识，对于不同的研究目的针对性地选择最具代表性额动物种属仍然有一定的局限性，我们更多的只能借助体外的代谢体系找到可能代谢特征与人体最接近的动物种属。

The cytochrome P-450 (CYP) drug metabolizing enzymes are essential for the efficient elimination of many clinically used drugs. These enzymes typically display high interindividual variability in expression and function resulting from enzyme induction, inhibition, and …

2014年7月18日 · Since mechanistic insight into species differences is needed to translate findings in this species to human, abundances of cytochrome P450 (CYP) and uridine diphosphate glucuronosyltransferase (UGT) drug metabolizing enzymes have been quantified in …

In this review the authors describe similarities and differences in this respect among the different species, including man. This may be helpful for drug researchers to choose the most relevant animal species in which the metabolism of a compound can be studied for extrapolating the results to humans.

Cytochrome P450 (CYP) drug metabolizing enzymes play an important role in efficient drug metabolism and elimination. Many CYPs are polymorphic and, thereby, drug metabolism can vary between individuals. In the case of canine CYP2C41, gene polymorphism was identified.

Essential drug-metabolizing enzymes, such as the cytochromes P450 (P450s or CYPs), have been analyzed in dogs, which are frequently used during drug development. Dog CYP3A12, CYP3A26, CYP3A98, and CYP3A99 have been previously identified and analyzed, and in this study, novel dog CYP3A293 cDNA was isolated.

2013年6月17日 · Isolation of a new canine cytochrome P450 CDNA from the cytochrome P450 2C subfamily (CYP2C41) and evidence for polymorphic differences in its expression

Absolute quantitation of drug-metabolizing cytochrome P450 enzymes and accessory proteins in dog liver microsomes using label-free standard-free analysis reveals interbreed variability

2024年10月1日 · Newly identified dog CYP3A98, a testosterone 6β- and estradiol 16α-hydroxylase, is abundantly expressed in small intestine and is likely the major CYP3A enzyme in small intestine, whereas dog CYP3A12 is the major CYP3A enzyme in liver. The roles of recently identified dog CYP2J2 and pig CYP2J33/34/35 were investigated.