UGT酶的两面性──解毒还是引发毒性？如何识别和评估酰基葡萄糖 …
常见的参与药物代谢的酶中，占比最大的是 cyp酶 ，它主导药物的Ⅰ相代谢过程。ugt酶（尿苷二磷酸葡萄糖醛酸转移酶）占比第二，是人体Ⅱ相代谢中最重要的酶之一，参与着很多药物的代 …
Mutual Influence of Human Cytochrome P450 Enzymes and UDP ...
In this study, we recombinantly co-expressed of each one of the 19 human members of the UGT families 1 and 2 with either CYP2C9, CYP2D6, or CYP4Z1 in fission yeast. Using these …
Chapter 12 Cytochrome p450 (cyp) and udp-glucuronosyltransferase (ugt ...
2005年1月1日 · This chapter focuses on CYP enzymes for Phase I metabolism and UDP-glucuronosyltransferase (UGT) enzymes for Phase II metabolism. Understanding the …
CYP450和UGT超级家庭成员从转录组的鉴定和分析
细胞色素P450（CYP450）和UDP糖基转移酶（UGT）基因超家族的成员在次级代谢产物的生物合成中起着重要的调节作用。 然而，系统鉴定CYP450s和UGTs在国内外尚未见报道 Aralia …
Functional Interaction between Cytochrome P450 and UDP
Cytochrome P450 (P450) and uridine 5'-diphosphate (UDP)-glucuronosyltransferase (UGT) catalyze oxidation and glucuronidation in drug metabolism, respectively. It is believed that …
The potential impact of CYP and UGT drug-metabolizing enzymes …
Examples of CYP- and UGT-mediated drug metabolism within the brain are presented at the end, illustrating the pivotal role of these enzymes in drug therapy and potential toxicity. In …
Full article: The potential impact of CYP and UGT drug …
2023年10月27日 · In summary, the expression patterns of CYP and UGT enzymes in the brain exhibit both similarities and differences across species. The CYP1A, 1B, 2D, and 2E and …
UDP‐Glucuronosyltransferase (UGT)‐mediated attenuations of …
Two drug‐metabolizing enzymes, cytochrome P450 (CYP) and UDP‐glucuronosyltransferase (UGT) form complexes. UGT2B7 interacts with and suppresses CYP3A4 activity by inhibiting …
CYP酶家族：药物代谢的天使与恶魔 - 知乎 - 知乎专栏
cyp酶抑制分析是指通过测定某种化合物对cyp酶的活性的影响，来评估其是否具有药物-药物相互作用的潜在风险的方法。cyp酶抑制分析可以在体内或体外进行，其中体外方法更为常用，因为 …
A comprehensive review of UDP-glucuronosyltransferase and …
2015年2月1日 · UDP-glucuronosyltransferase (UGT) and esterases are recognized as the most important non-P450 enzymes because of their high contribution to drug metabolism. UGTs …
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