5 天之前 · CYP19A1 (Cytochrome P450 Family 19 Subfamily A Member 1) is a Protein Coding gene. Diseases associated with CYP19A1 include Aromatase Deficiency and Aromatase Excess Syndrome. Among its related pathways are Oxidation by cytochrome P450 and Metapathway biotransformation Phase I and II.

Aromatase (EC 1.14.14.14), also called estrogen synthetase or estrogen synthase, is an enzyme responsible for a key step in the biosynthesis of estrogens. It is CYP19A1, a member of the cytochrome P450 superfamily, which are monooxygenases that catalyze many reactions involved in steroidogenesis.

卵巢和胎盘有芳香化酶（aromatase，CYP19A1），也称为雌激素合成酶，可催化A环芳构化，是雌性激素（雌酮和雌二醇等）合成的限速酶。 雌性激素合成。 引自themedicalbiochemistrypage

该基因的突变可导致芳香酶活性增加或降低；相关的表型表明，雌激素既可作为性类固醇激素，又可在生长或分化中发挥作用。 替代启动子的使用和替代剪接导致具有不同组织特异性的多个转录变体。 [RefSeq 提供，2016 年 12 月] This gene encodes a member of the Cytochrome P450 superfamily of Enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and Other …

The CYP19A1 gene provides instructions for making an enzyme called aromatase. This enzyme converts a class of hormones called androgens, which are involved in male sexual development, to different forms of the female sex hormone estrogen.

CYP19A1 was the only gene harboring single nucleotide polymorphisms that were significantly associated with prostate cancer risk; CYP19A1 mRNA expression and aromatase activity during syncytialization of primary human villous trophoblast cells at term; in postmenopausal women, aromatase activity could be an important determinant of skeletal health.

2025年2月8日 · Obesity-associated white adipose tissue inflammation leads to increased peripheral CYP19A1 expression in males. Neonatal testosterone acts via ESR1 in an aromatase dependent manner to suppress central pattern generators required for pulsatile oxytocin release.

2025年2月8日 · Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation.

cyp19a1作为调控雄激素向雌激素转化的关键酶，在结直肠癌的发展过程中亦扮演着重要的角色。在最新研究中发现cyp19a1高表达与结直肠癌患者不良预后显著相关，并且可能与晚期病理分期有关，且cyp19a1会促进crc的增殖和迁移 。

Characterization of a novel CYP19A1 (aromatase) R192H mutation causing virilization of a 46,XX newborn, undervirilization of the 46,XY brother, but no virilization of the mother during pregnancies. Sequencing of cDNA inserts encoding aromatase cytochrome P-450 (P-450AROM). 这个基因编码细胞色素P450超家族酶的一员。 细胞色素P450蛋白是单加氧酶，催化许多与药物代谢和胆固醇、类固醇和其他脂质合成有关的反应。