This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.

Cytochrome P450 2B6 (CYP2B6) is involved in the metabolism of antiretroviral, antimalarial, anticancer, and antidepressant drugs. These drug classes are commonly in use worldwide and face specific population variability in side effects and dosing.

2024年12月24日 · CYP2B6 (Cytochrome P450 Family 2 Subfamily B Member 6) is a Protein Coding gene. Diseases associated with CYP2B6 include Efavirenz, Poor Metabolism Of and Major Depressive Disorder. Among its related pathways are Oxidation by cytochrome P450 and Metapathway biotransformation Phase I and II.

In this review, we will provide an overview of the key players in CYP2B6 expression and function and highlight recent advances made in assessing clinical ramifications of important CYP2B6-mediated drug–drug interactions.

CYP2B6 is the only gene in the human CYP2B subfamily encoding functional enzyme. CYP2B6 is mainly expressed in the liver and, to substantially smaller extents, in extrahepatic tissues such as the alimentary tract, kidney, lung and brain according to …

Gene ID: 1555, updated on 8-Feb-2025. This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.

CYP2B6 is one of the most polymorphic CYP genes in humans and variants have been shown to affect transcriptional regulation, splicing, mRNA and protein expression, and catalytic activity.

2025年1月4日 · This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.

CYP2B6 is one of the most polymorphic CYP genes in humans with over 100 described SNPs, numerous complex haplotypes and distinct ethnic and racial frequencies. This review summarizes the basic properties of CYP2B6 and the main characteristics of clinical relevance.

CYP2B6 is an enzyme that plays a major role in drug metabolism in the liver, particularly in infants older than 1 year. It is expressed at low levels in comparison to other CYP enzymes, and its complete maturation takes at least 1 year. AI generated definition based on: Drug Metabolism in Diseases, 2017