May 25, 2009 · CAAX proteins are widely involved in global cellular functions such as proliferation, differentiation, and carcinogenesis. As an important modulator of biological activity, signal transduction via protein prenylation is a crucial step for most CAAX protein functions, particularly for anchoring these …

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异戊烯化蛋白调控CAAX蛋白的功能是通过研究FTase抑制RAS蛋白的信号通路过程中发现的。 RCE-1蛋白水解的影响 在小鼠中通过基因干扰手段，发现RCE-1蛋白是唯一可以水解大部分的CAAX蛋白。

Dec 1, 2013 · CAAX proteins have essential roles in multiple signalling pathways, controlling processes such as proliferation, differentiation and carcinogenesis 1.

Plasmid EGFP-CAAX from Dr. Lei Lu's lab contains the insert Homo sapiens Harvey rat sarcoma and is published in J Cell Sci. 2016 Oct 15;129(20):3922-3934. Epub 2016 Sep 15. This plasmid is available through Addgene.

Nov 12, 2020 · 蛋白异戊烯修饰基于基因抑制以及药理学的抑制剂的相关机制，已经在不同细胞过程和疾病病理学方面深入研究。 大部分异戊烯化蛋白是 CAAX 蛋白，异戊烯修饰通常是通过蛋白法酰基转移酶（FTase）或者蛋白香叶酰基转移酶（GGTase I）分别将 C15 （法酰基）或者 C20 （香叶酰基）链接在半胱氨酸（Cys）残基上。 这个酶促反应如果是有法尼基参与，那么就是法尼酰化修饰，如果是香叶酰基参与，那么就是香叶酰化修饰。 然后，蛋白可以被 Ras- 转换内肽 …

Jul 9, 1999 · In this model, farnesylated ras proteins interact with specific receptors in the endomembrane system, perhaps the prenylcysteine-CAAX protease itself, are acted upon by the endomembrane resident prenyl-CAAX processing enzymes, and are then released to one or more transport pathways that bring them to the PM.

FTase优先选择X残基为丙氨酸、丝氨酸、蛋氨酸或谷氨酰胺的CaaX序列，而亮氨酸、异亮氨酸和苯丙氨酸是GGTase-I的首选。 这种底物特异性并非互斥，K-Ras和Rho B蛋白就表现出重叠的特异性。

CAAX是一种氨基酸序列，包括Cys（半胱氨酸）、Ala（丙氨酸）、任意的氨基酸（X），以及最后的Cys。CAAX基序在蛋白质后面，通常用于表征酶修饰（如脂肪酰化和葡萄糖酰化）和膜锚定的蛋白质。CAAX基序中的半胱氨酸通

Jan 1, 2002 · This chapter deals primarily with the biochemistry and biology of protein prenylation, focusing on those proteins that contain a so-called CaaX motif at their C-terminus. The C-terminal processing of CaaX proteins is initiated by addition of either a farnesyl or geranylgeranyl isoprenoid to the conserved cysteine of the CaaX motif.