The histone chaperone CAF-1 safeguards somatic cell identity
2015年12月9日 · Together, our findings reveal the histone chaperone CAF-1 to be a novel regulator of somatic cell identity during transcription-factor-induced cell-fate transitions and …
Chromatin assembly factor 1 - Wikipedia
Chromatin assembly factor-1 (CAF-1) is a protein complex — including Chaf1a (p150), Chaf1b (p60), and p48 subunits in humans, or Cac1, Cac2, and Cac3, respectively, in yeast— that …
Science | 揭示染色质组装因子CAF-1介导核小体装配的结构基础
2023年8月25日，中国科学院生物物理研究所许瑞明、李国红、 朱冰 及刘超培共同通讯在 Science 在线发表题为“ Structural insights into histone binding and nucleosome assembly by …
Regulation of chromatin accessibility by the histone chaperone CAF-1 …
2022年4月29日 · We show that CAF-1 suppression triggers rapid differentiation of myeloid stem and progenitor cells into a mixed lineage state. We find that CAF-1 sustains lineage fidelity by …
CAF-1在体细胞重编程中的作用机制 - 仁和软件
CAF-1主要功能是在DNA复制中与增殖细胞核抗原（proliferating cell nuclear antigen，PCNA）相互作用，负责募集组蛋白H3、H4沉积在新合成的DNA上以促进核小体装配。 越来越多的研究 …
Histone chaperone networks shaping chromatin function
2017年1月5日 · The CAF1 complex binds to PCNA to promote deposition during DNA replication (part a) and DNA repair (part b), whereas the HIRA complex may be recruited by naked DNA …
CAF-1 deposits newly synthesized histones during DNA ... - PubMed
2023年5月8日 · Chromatin Assembly Factor-1 (CAF-1) is a key regulator of chromatin replication, but how CAF-1 functions in relation to the DNA replication machinery is unknown. Here, we …
The role of the chromatin assembly complex (CAF-1) and its p60 ... - PubMed
Here, we review the biology of the CAF-1 complex, with an emphasis on CHAF1b, including its structure, regulation, and function. In addition, we discuss the possible contributions of …
生物物理所揭示染色质组装因子CAF-1介导核小体装配的结构基础
2023年8月25日 · 染色质组装因子CAF-1是在进化过程中保守的异源三聚体组蛋白伴侣复合物，负责将新合成的H3-H4组蛋白装配到子链DNA上，完成从头装配的核小体组装的第一步，即形成 …
Histone chaperone CAF-1: essential roles in multi-cellular …
2014年10月8日 · In this review, we will focus on the developmental roles of another histone chaperone, chromatin assembly factor 1 (CAF-1). Over two decades ago, CAF-1 was first …