碳酸酐酶IX（Carbonic Anhydrase IX，简称CAIX或CA9）是一种在缺氧实体瘤中特异性高表达的跨膜蛋白，其独特的生理功能和在肿瘤发展中的作用使其成为肿瘤成像和治疗的重要靶点。

碳酸酐酶IX (carbonic anhydrase IX, CAIX，CA9)是一个由459个氨基酸组成的跨膜蛋白，由四个结构域组成：N端蛋白多糖样结构域（PG）、CA催化结构域（CA）、单通螺旋跨膜区和短的胞内尾巴。

CO 2 venting is further supported by the catalytic function of the extracellular carbonic anhydrase (CA) isoforms CAIX and CAXII (the latter one is omitted from this cartoon for clarity)....

2022年2月16日 · We compared the 41BB endodomain and the CD2 domain, which has shown preliminary effects reducing cytokine release. We hypothesized that these changes would increase efficacy in immune-suppressive solid tumors while reducing excessive cytokine release and untoward immune toxicity.

Carbonic anhydrase IX (CAIX) which is a zinc containing metalloprotein, efficiently catalyzes the reversible hydration of carbon dioxide. It is constitutively up-regulated in several cancer types and has an important role in tumor progression, acidification and metastasis.

CAIX activity results in extracellular acidosis and in a profound reorganization of the tumor micro-environment, influencing biological behavior and prognosis. The main focus of our study was to evaluate the mass and distribution of the immune infiltrate, more specifically of CD8+ effector T-cells, in relation with tumoral CAIX expression.

2022年11月1日 · CAIX helps tumors deal with higher CO 2 by sequestering it with bicarbonate ions and helping cancer cells to grow in a comparatively hypoxic or acidic environment, thus acting as a pH adaptation switch. CAIX-mediated adaptations in cancer cells include angiogenesis, metabolic alterations, tumor heterogeneity, drug resistance, and regulation of ...

2023年5月30日 · 碳酸酐酶IX (carbonic anhydrase IX, CAIX，CA9)是一个由459个氨基酸组成的跨膜蛋白，由四个结构域组成：N端蛋白多糖样结构域（PG）、CA催化结构域（CA）、单通螺旋跨膜区和短的胞内尾巴。 CAIX生理作用通常与酸碱平衡以及二氧化碳和碳酸氢盐的转运有关，能够调节细胞内 (pHi)和细胞外 (pHe)pH值平衡并导致缺氧和酸性肿瘤微环境。 细胞外微环境（缺氧和pH值）的影响已被认为是癌症进展的一个关键标志。 CAIX作为一个关键的缺氧诱导标记物， …

2023年11月24日 · 在针对CAIX的免疫治疗药物中，进展最快的是 远大医药 /Telix开发的适用于 透明细胞肾细胞癌 (ccRCC) 诊断的 放射性核素偶联药物 （RDC）药物TLX250-CDx(89Zr-DFO-girentuximab)，其中Girentuximab是一种IgG1 kappa 轻链嵌合单克隆抗体，可特异性结合CAIX，随后被内化。TLX250-CDx已于 ...

2019年11月4日 · Herein, we aim to (i) develop chimeric antigen receptor (CAR) T cells with a specificity to a unique antigen, carbonic anhydrase IX (CAIX), which is expressed in the hypoxic microenvironment characteristic of glioblastoma, and (ii) demonstrate its …