Calcifediol, also known as calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D 3 (abbreviated 25(OH)D 3), [1] is a form of vitamin D produced in the liver by hydroxylation of vitamin D 3 (cholecalciferol) by the enzyme vitamin D 25-hydroxylase.

2025年2月3日 · Calcifediol is a vitamin D3. Vitamin D is important for the absorption of calcium from the stomach and for the functioning of calcium in the body. Calcifediol is used to treat secondary hyperparathyroidism (overactive parathyroid glands) in adults who have stage 3 or 4 chronic kidney failure and low vitamin D levels.

Vitamin D supplementation represents an important topic in the field of metabolic bone disease. Calcidiol, the 25-hydroxy-vitamin D [25 (OH)D], is the form of vitamin D most recently introduced in clinical practice.

2025年2月1日 · Calcifediol is a vitamin D3 analog that is used to treat secondary hyperparathyroidism in adult patients with stage 3 or 4 chronic kidney disease and serum total 25-hydroxyvitamin D levels less than 30 ng/mL. Hyperparathyroidism is a condition that is caused when the parathyroid glands located in the neck make too much parathyroid hormone (PTH).

2024年6月7日 · Here, your body converts vitamin D to a chemical known as 25-hydroxyvitamin D, also called calcidiol. The 25-hydroxy vitamin D test is the best way to monitor vitamin D levels. The amount...

Natural vitamin D 3 (cholecalciferol) is synthesized in the skin through ultraviolet radiation (sun exposure) (Figure 3), while small amounts of vitamin D 2 (ergocalciferol) are contained in the diet. Both components are metabolized, in the liver, to 25-hydroxyvitamin D (calcidiol) (Figure 3).

Calcifediol differs pharmacokinetically from vitamin D 3 in several ways. It is independent of hepatic 25-hydroxylation and thus is one step closer in the metabolic pathway to active vitamin D.

Calcifediol is an active metabolite of vitamin D used to treat hyperparathyroidism as well as to combat hypocalcemia in dialysis patients. The major circulating metabolite of vitamin D3 (cholecalciferol). It is produced in the liver and is the best indicator of the body's vitamin D stores.

Calcitriol is a calciotropic hormone that functions as a steroid through its binding to the intracellular vitamin D receptor (VDR) [15], a member of the steroid nuclear receptor superfamily, which comprises thyroid hormones, retinoic acid, sex hormones, and adrenal steroids, resulting in the modulation (activation or suppression) of gene express...

Calcidiol is a hydroxycalciol that is calciol in which the hydrogen at position 25 has been replaced by a hydroxy group. A prehormone resulting from the oxidation of calciol in the liver, it is further hydroxylated in the kidney to give calcitriol, the active form of vitamin D3.