A calpain (/ ˈkælpeɪn /; [1] EC 3.4.22.52, EC 3.4.22.53) is a protein belonging to the family of calcium -dependent, non-lysosomal cysteine proteases (proteolytic enzymes) expressed ubiquitously in mammals and many other organisms. Calpains constitute the C2 family of protease clan CA in the MEROPS database.

Calpain-2 (EC 3.4.22.53, calcium-activated neutral protease II, m-calpain, milli-calpain) is an intracellular heterodimeric calcium-activated cysteine protease. [1][2] This enzyme catalyses the following chemical reaction. This enzyme belongs to the peptidase family C2. It is one of 15 proteins in the calpain family. [3]

Calpains are a 15-member class of calcium activated nonlysosomal neutral proteases which are involved in a broad range of cellular function. Calpains are usually localized to the cytosol and within mitochondria. Calpastatin is an endogenous protein that specifically binds to …

The calpain system originally comprised three molecules: two Ca2+-dependent proteases, mu-calpain and m-calpain, and a third polypeptide, calpastatin, whose only known function is to inhibit the two calpains.

2021年5月1日 · Calpains are calcium-dependent cysteine proteases. The members of the calpain family can have a classical or a non-classical structural organisation. Calpains as proteases require a number of mechanisms to control their activity from spatio-temporal modifications of expression to changes in molecular conformation.

2021年8月21日 · Calpain is a conserved family of calcium-dependent, cytosolic, neutral cysteine proteases. The best characterized members of the family are the ubiquitously expressed calpain 1 and calpain 2. They perform controlled proteolysis of their target proteins.

2005年6月9日 · Calpains are Ca 2+ -dependent cysteine proteases (proteolytic enzymes with cysteine in the catalytic site) that modulate cellular function. In humans, 14 independent genes encode members of the...