Calponin is a calcium binding protein. Calponin tonically inhibits the ATPase activity of myosin in smooth muscle. Phosphorylation of calponin by a protein kinase, which is dependent upon calcium binding to calmodulin, releases the calponin's inhibition of the smooth muscle ATPase.

Calponin (类肌钙蛋白)是一个肌动蛋白细肌丝相关的调节蛋白,表达在平滑肌细胞和许多类型的非肌细胞中.哺乳动物有Calponin 1,Calponin 2和Calponin 3三个亚型,分别由三个同源基因CNN1,CNN2和CNN3编码,表达于不同的细胞类型,并执行细胞类型特异性的生理功能.除了调节平滑肌收缩功能,Calponin还调节非肌细胞肌动蛋白骨架的功能并参与多种细胞生命活动,如增殖,粘附,迁移,分化,吞噬和细胞融合等.本综述重点讨论Calponin亚型的基因进化,组织和细胞类型特异性表 …

2024年2月29日 · Calponin属于平滑肌特异性蛋白，与肌动蛋白（actin）强力结合，而不依赖于Ca 2+ ，与平滑肌的收缩和调节有关。表达在正常的平滑肌细胞和肌上皮细胞 表达在正常的平滑肌细胞和肌上皮细胞

2023年6月23日 · Calponin and transgelin (originally named SM22) are homologous cytoskeleton proteins that regulate actin-activated myosin motor functions in smooth muscle contraction and non-muscle cell motility during adhesion, migration, proliferation, phagocytosis, wound healing, and inflammatory responses.

Calponin is an actin filament-associated regulatory protein expressed in smooth muscle and multiple types of non-muscle cells. Three homologous genes, CNN1, CNN2 and CNN3, encoding calponin isoforms 1, 2, and 3, respectively, are present in vertebrate species.

Calponin为一种平滑肌特有的调控蛋白, 分子克隆的证据表明, 它具有两种亚型, α型和β型分别由292和252个氨基酸组成它能与肌动蛋白结合, 抑制肌球蛋白ATP酶活性和平滑肌收缩其与肌动蛋白结合域有38个氨基酸残基(第145～182位), 丝氨酸175在调宁蛋白与肌动蛋白的 ...

Calponin is a smooth muscle–specific protein, similar to calmodulin, that binds strongly to actin in a calcium-independent manner and appears to be involved in the regulation of smooth muscle contraction.

Calponin is a troponin-T like protein purified from chicken gizzard smooth muscle. It binds to actin, myosin, Ca (2+)-binding proteins and tropomyosin and inhibits the actomyosin ATPase as well as the movement of actin filaments over myosin in vitro. These properties have led …

1996年11月1日 · Calponin is a troponin-T like protein purified from chicken gizzard smooth muscle. It binds to actin, myosin, Ca 2+ -binding proteins and tropomyosin and inhibits the actomyosin ATPase as well as the movement of actin filaments over myosin in vitro.

2016年7月1日 · Calponin is an actin filament-associated regulatory protein expressed in smooth muscle and many types of non-muscle cells. Three homologous genes, CNN1, CNN2 and CNN3, encoding calponin isoforms 1, 2, and 3, respectively, are present in vertebrate species.