2024年12月24日 · CAMK2D (Calcium/Calmodulin Dependent Protein Kinase II Delta) is a Protein Coding gene. Diseases associated with CAMK2D include Cardiomyopathy, Dilated, 1Dd and Hot Water Epilepsy. Among its related pathways are Calmodulin induced events and Signaling downstream of RAS mutants.

2025年3月8日 · CAMK2D serves as a molecular scaffold for RNF8-MAD2 complex to induce mitotic checkpoint in glioma. TRPM1 promotes tumor progression in acral melanoma by activating the Ca [2+]/CaMKIIdelta/AKT pathway. miR-145-5p affects autophagy by targeting CaMKIIdelta in …

Calcium/calmodulin-dependent protein kinase type II delta chain is an enzyme that in humans is encoded by the CAMK2D gene. [5] The product of this gene belongs to the serine/threonine protein kinase family and to the Ca 2+ /calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at ...

2023年7月21日 · CAMK2D was highly expressed in 70% of the human MMe tissues (56/80) and correlated with the loss of BAP1 expression, making it a potential diagnostic and therapeutic target for BAP1 -deficient...

Ca 2+ /calmodulin stimulated protein kinase kinase (CaMKK) is a multifunctional protein kinase encoded by two genes (CAMKK1 and CAMKK2) that produce CaMKKα or CaMKKβ [3], respectively. The CAMKK2 gene produces several splicing isoforms depending on cell type [4, 5].

2024年2月1日 · Here we show that CAMK2D plays an important role in neurodevelopment not only in mice but also in humans. We identified eight individuals harboring heterozygous variants in CAMK2D who display symptoms of intellectual disability, delayed speech, behavioral problems, and dilated cardiomyopathy.

2025年2月8日 · CaM Kinase II-delta Is Required for Diabetic Hyperglycemia and Retinopathy but Not Nephropathy. Phosphorylation of T107 by CamKIIdelta Regulates the Detoxification Efficiency and Proteomic Integrity of Glyoxalase 1.

该基因的产物属于丝氨酸/苏氨酸蛋白激酶家族和 CA (2+) /钙调蛋白依赖性蛋白激酶亚家族。 钙信号对于谷氨酸能突触可塑性的几个方面至关重要。 在哺乳动物细胞中，这种酶由四种不同的 …

2021年5月10日 · CAMK2D was found to be the direct target of miR-135b, serving as a tumor suppressor in GC cells. Based on our and public datasets, we confirmed the attenuation of CAMK2D expression in GC tissues. And, the expression levels of miR-135b and CAMK2D were closely associated with prognosis of GC patients.

Calcium/calmodulin-stimulated protein kinase II (CaMKII) is a family of multi-functional serine (Ser)/threonine (Thr) protein kinases (α, β, γ, and ∂), encoded by four genes (CAMK2A, CAMK2B, CAMK2G, and CAMK2D) [1]. One or more members of this family are expressed in almost every tissue, and control diverse functions.