2024年12月24日 · CAMK2G (Calcium/Calmodulin Dependent Protein Kinase II Gamma) is a Protein Coding gene. Diseases associated with CAMK2G include Intellectual Developmental Disorder, Autosomal Dominant 59 and Alacrima, Achalasia, And Impaired Intellectual Development Syndrome.

Calcium/calmodulin-dependent protein kinase type II gamma chain is an enzyme that in humans is encoded by the CAMK2G gene. [5] The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca (2+)/calmodulin-dependent protein kinase subfamily.

2025年2月8日 · CAMK2G is identified as a novel therapeutic target for myelofibrosis. Matrine suppresses cell growth of diffuse large B-cell lymphoma via inhibiting CaMKIIgamma/c-Myc/CDK6 signaling pathway. A physiologic rise in cytoplasmic calcium ion signal increases pannexin1 channel activity via a C-terminus phosphorylation by CaMKII.

CAMK2G knockdown inhibited neurite outgrowth and down-regulated neuronal differentiation markers (NF-H, MAP2), yet promoted migration, invasion and proliferation. Gene Ontology (GO) analysis showed that knockdown of CAMK2G downregulated the expression of neuronal differentiation-related genes.

2025年2月8日 · Enables calcium/calmodulin-dependent protein kinase activity. Involved in regulation of neuron projection development and regulation of relaxation of cardiac muscle. Acts upstream of or within G1/S transition of mitotic cell cycle; calcium ion transport; and protein autophosphorylation. Located in postsynaptic density.

Ubiquitous expression in brain (RPKM 28.7), prostate (RPKM 10.9) and 24 other tissues. 该基因的产物是属于丝氨酸/苏氨酸蛋白激酶家族和 CA (2+) /钙调蛋白依赖性蛋白激酶亚家族的酶的 …

2022年9月2日 · Calcium–calmodulin (CaM)-dependent protein kinase II (CaMKII) is the most abundant protein in excitatory synapses and is central to synaptic plasticity, learning and memory....

Calcium/calmodulin-dependent protein kinase II (CaMKII) regulates tumour necrosis factor-related apoptosis inducing ligand (TRAIL)-mediated apoptosis of fibroblast-like synovial cells (FLS) by phosphorylation of Akt.

2022年3月8日 · We showed that CAMK2G hetero knockout in the primary bone marrow cells expressing MPL W515L decreased colony-forming capacity. CAMK2G inhibition with berbamine, a CAMK2G inhibitor, significantly prolonged survival and reduced disease phenotypes, such as splenomegaly and leukocytosis in a MF mouse model induced by MPL W515L.

该基因编码的蛋白可启动蛋白质丝氨酸/苏氨酸激酶活性。 参与神经元投射发育的调节和心肌松弛的调节。 作用于有丝分裂细胞周期 G1/S 转换的上游或内部；钙离子运输；和蛋白质自身磷酸化。 位于突触后密度。 以多种结构表达，包括消化系统；中枢神经系统;泌尿生殖系统；外皮系统；和感觉器官。 该基因的人类直系同源物与常染色体显性非综合征性智力障碍有关。 与人 CAMK2G（钙/钙调蛋白依赖性蛋白激酶 II γ）同源。 [由基因组资源联盟提供，2022 年 4 月] …