High-throughput Analysis of Capillary Density in Skeletal Muscle …
2024年1月24日 · Here, we present a step-by-step, high-throughput semi-automated method for quantifying capillary density from whole human skeletal muscle cross-sections, in areas of the muscle occupied by myofibers. We provide a detailed protocol for immunofluorescence staining, image acquisition, processing, and quantification.
Estimation of capillary density in human skeletal muscle based …
2003年12月1日 · A previously developed Krogh-type theoretical model was used to estimate capillary density in human skeletal muscle based on published measurements of oxygen consumption, arterial partial pressure of oxygen, and blood flow during maximal exercise.
Skeletal muscle capillary density is related to anaerobic …
Exercise intolerance may result from reduced skeletal muscle capillary density and impaired muscle oxygen delivery. This cross-sectional study tested the hypothesis that capillary density is related to claudication times and anaerobic threshold (AT) in patients with PAD.
SKELETAL MUSCLE CAPILLARY FUNCTION: CONTEMPORARY …
Presumption: Structural capillary density is the major determinant of muscle O 2 diffusing capacity. Current perspective: Federspiel & Popel (1986) and Groebe & Thews (1990) have developed theoretical models positing that the primary determinant of muscle O 2 diffusing capacity must be the number of RBCs in the capillaries adjacent to the ...
Peripheral limitations for performance: Muscle capillarization ...
2023年9月28日 · Studies show that capillaries are tortuous, situated along and across the length of the fibers with an arrangement related to muscle fascicles. Although direct data is lacking, it is possible that years of training not only enhances capillary density but also optimizes the positioning of capillaries, to further improve the diffusion conditions.
However, there are relatively few studies showing capillary growth in adult normal muscle or heart in this way, most of the data being based on capillary counts, either per mm2 (capillary density, CD) or expressed as capillary:fiber (C:F) ratio.
2003年6月16日 · mating capillary density in skeletal muscle. The model was used to estimate the minimum number of straight, evenly spaced capillaries per unit muscle cross-sec-tional area required to achieve a given observed oxygen consumption rate. Estimates are based on measure-ments of muscle oxygen consumption, arterial PO2, and muscle blood flow made at ...
Training for skeletal muscle capillarization: a Janus-faced role of ...
2016年6月24日 · Muscle capillarization is central for the delivery of oxygen and nutrients to the exercising muscle, and thus, capillarization is vital for exercise capacity. A high muscle capillary density means a large muscle-to-blood exchange surface area, short oxygen diffusion distance, and high red blood cell mean transit time.
Capillary density of skeletal muscle: A contributing mechanism …
1999年6月1日 · We postulate that a decreased capillary density to the working muscles may contribute to the earlier onset of skeletal muscle anaerobic metabolism in ambulatory patients with class II–III CHF. Interplay between cardiac output and skeletal muscle
Estimation of capillary density in human skeletal muscle based …
A previously developed Krogh-type theoretical model was used to estimate capillary density in human skeletal muscle based on published measurements of oxygen consumption, arterial partial pressure of oxygen, and blood flow during maximal exercise.
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