2024年12月24日 · CAPN10 (Calpain 10) is a Protein Coding gene. Diseases associated with CAPN10 include Type 1 Diabetes Mellitus 2 and Polycystic Ovary Syndrome. Among its …

It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It therefore cannot heterodimerize with the small subunit. It is …

2025年2月10日 · CAPN10 alleles are associated with polycystic ovary syndrome; We show that the diabetes gene calpain-10 (CAPN10) plays a role in atherosclerosis, insulin sensitivity and …

CAPN10, which encodes the cysteine protease calpain 10, was the first type 2 diabetes mellitus (T2DM) susceptibility gene identified through a genome-wide scan followed by positional …

2018年11月13日 · Calpain-10 (CAPN10) is a member of the atypical calpain group, and was identified as the first susceptibility gene for T2DM 2. The development of T2DM involves …

CAPN10 is ubiquitously distributed, and its cellular localization is dynamic. When localized to the mitochondria, it mediates mitochondrial dysfunction by cleaving Complex I subunits and …

It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is …

It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is …

2025年1月4日 · It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. …

The CAPN10 gene encodes a ubiquitously expressed member of the calpain-like cysteine protease family. The 672 amino-acid protein shares 81.7% identity with the mouse ortholog. …