2023年6月14日 · We used base editing to generate universal, off-the-shelf chimeric antigen receptor (CAR) T cells. Healthy volunteer donor T cells were transduced with the use of a lentivirus to express a CAR with...

Gene ID: 12354, updated on 8-Feb-2025. Enables carbonate dehydratase activity. Acts upstream of or within several processes, including positive regulation of GABAergic synaptic transmission; positive regulation of cellular pH reduction; and regulation of chloride transport. Located in cytosol.

Homology Homologs of the Car7 gene: The Car7 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, A.thaliana, …

2023年6月14日 · We then used base editing to inactivate three genes encoding CD52 and CD7 receptors and the β chain of the αβ T-cell receptor to evade lymphodepleting serotherapy, CAR7 T-cell fratricide, and graft-versus-host disease, respectively. We investigated the safety of these edited cells in three children with relapsed leukemia.

2023年6月14日 · 使用慢病毒转导健康志愿者供体T细胞，以表达对CD7（CAR7）具有特异性的CAR，该蛋白在T细胞急性淋巴细胞白血病（ALL）中表达。 然后，研究组使用碱基编辑使编码CD52和CD7受体以及αβ T细胞受体的β链的三个基因失活，以分别逃避淋巴消耗血清疗法、CAR7 T细胞自相残杀和移植物抗宿主病。 并研究了这些编辑细胞在三名复发性白血病儿童中的安全性。 第一名患者是一名13岁女孩，她在异基因干细胞移植后复发了T细胞ALL，在输注单剂量碱基 …

Predicted to enable carbonate dehydratase activity. Predicted to be involved in regulation of intracellular pH. Predicted to act upstream of or within several processes, including positive regulation of GABAergic synaptic transmission; positive regulation of cellular pH reduction; and regulation of chloride transport.

View mouse Car7 Chr8:105261326-105276979 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression

The spatial expression patterns of the two alpha-carbonic anhydrase genes, CA VII and CA-RP VIII (called Car7 and Car8 in the mouse) were examined in the mouse brain by in situ hybridization. These two genes are the most highly conserved evolutionarily among the mammalian alpha-CAs.

Located in cytosol. Is expressed in several structures, including brain and genitourinary system. Orthologous to human CA7 (carbonic anhydrase 7). [provided by Alliance of Genome Resources, Apr 2022] 原英文文本： 原翻译后文本： 修改意见： 0 / 2000 直系基因 【大鼠】 Car7 【人类】 …

Discover mouse gene Car7 significant phenotypes, expression, images, histopathology and more. Data for gene Car7 is freely available to download.