Carbapenem-resistant Klebsiella pneumoniae capsular types, …
2024年2月29日 · Carbapenem-resistant Klebsiella pneumoniae (CRKP) has emerged as a major public health threat 1 due to its multidrug-resistant nature and ability to cause infections with high mortality rates 2.
Carbapenem-Resistant Klebsiella pneumoniae - PubMed …
High-Level Carbapenem Resistance in a Klebsiella pneumoniae clinical isolate is due to the combination of bla ACT-1 β-Lactamase production, porin OmpK35/36 insertional inactivation, and down-regulation of the phosphate transport porin PhoE.
Carbapenem-Resistant Klebsiella pneumoniae : Virulence …
2023年1月21日 · Infections caused by carbapenem-resistant K. pneumoniae (CRKP) constitute a major threat for public health and are strongly associated with high rates of mortality, especially in immunocompromised and critically ill patients.
Carbapenem-Resistant Klebsiella pneumoniae in Large Public …
Controlling the spread of carbapenem-resistant Enterobacterales is a global priority. Using National Healthcare Safety Network data, we characterized the changing epidemiology of carbapenem-resistant Klebsiella pneumoniae (CRKP) in a large public health system in New York, New York, USA.
Antimicrobial Resistance, Hypervirulent Klebsiella pneumoniae
2024年7月31日 · The aim was to rapidly assess the current global situation given the increased identification of isolates of hypervirulent Klebsiella pneumoniae (hvKp) sequence type (ST) 23 carrying resistant genes to the carbapenem antibiotics – carbapenemase genes – reported in several countries.
Guidance for Control of Infections with Carbapenem-Resistant or ...
2009年3月19日 · Currently, carbapenem-resistant Klebsiella pneumoniae (CRKP) is the species of CRE most commonly encountered in the United States. CRKP is resistant to almost all available antimicrobial agents, and infections with CRKP have been associated with high rates of morbidity and mortality, particularly among persons with prolonged hospitalization and ...
Understanding carbapenem-resistant hypervirulent Klebsiella pneumoniae ...
2024年6月26日 · Diverse virulence genes in both the core and accessory genomes contribute to the hypervirulence of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CRhvKP). The highly variable genome represents potential factors underlying the epidemic success of sequence type 11 CRhvKP.
Recent advances in the understanding and management of Klebsiella …
This report estimated that, in the US each year, there are 7,900 infections and 520 deaths due to carbapenem-resistant Klebsiella species. KPC is the most common mechanism of carbapenem resistance among K. pneumoniae isolates in the US. As of January 2017, KPC-producing CRE had been reported to the CDC from 48 states in the US 17. KPC-producing ...
Treatment and Outcomes in Carbapenem-resistant Klebsiella pneumoniae ...
Carbapenem-resistant K. pneumoniae (CR-Kp) is an emerging multi-drug resistant nosocomial pathogen. This is a retrospective chart review describing the outcomes and treatment of 60 cases of CR-Kp bloodstream infections.
Review of therapeutic options for infections with carbapenem-resistant
Infections with multi-drug resistant (MDR) bacteria including carbapenem-resistant Klebsiella pneumoniae are emerging worldwide but are difficult to treat with the currently available antibiotic compounds and therefore constitute serious threats to human health.