2023年4月16日 · A carboxylic acid is an organic compound that contains the carboxyl functional group. The general formula for a carboxylic acid can be abbreviated as \(\ce{R-COOH}\). Many carboxylic acids are used in the food and beverage industry for flavoring and/or as preservatives. An ester has an OR group attached to the carbon atom of a carbonyl group.

The enzyme carboxylesterase (or carboxylic-ester hydrolase, EC 3.1.1.1; systematic name carboxylic-ester hydrolase) catalyzes reactions of the following form: [1] a carboxylic ester + H 2 O ⇌ {\displaystyle \rightleftharpoons } an alcohol + a carboxylate

该类药物的设计目标为soft drug进入肠道上皮细胞发挥药效，在肝脏被CES酶水解，避免soft drug入系统循环造成副作用。 而人体中CES1分布于肝脏，CES2分布于肠道，因此CES1的底物更符合目标，多设计为小醇大酸类化合物。 DMPK的筛选目标希望为吸收性质良好（溶解度高，渗透性高），较低的肠道代谢（肠道代谢稳定性良好），当时肝脏首过代谢极高（肝微粒体或肝细胞极其不稳定）。 依据化合物的药效发挥能力和安全性问题的严重性进行权衡其吸收能力和肝脏 …

In the human body, two predominant carboxylesterases (CES1 and CES2) have been identified and extensively studied over the past decade. These two enzymes play crucial roles in the metabolism of a wide variety of endogenous esters, ester …

Carboxylic esters are liquids or solids with distinct aromas that can be isolated from essential oils and waxes. They are often used as artificial essences for flavoring purposes and have lower melting and boiling points compared to similar molecular weight carboxylic acids.

An ester of a carboxylic acid. R stands for any group (typically hydrogen or organyl) and R ′ stands for any organyl group. In chemistry, an ester is a compound derived from an acid (organic or inorganic) in which the hydrogen atom (H) of at least one acidic hydroxyl group (−OH) of that acid is replaced by an organyl group (R ′). [1]

2002年3月1日 · Beside lipases, a considerable number of microbial carboxyl esterases have also been discovered and overexpressed. This review summarizes their properties and classification. Special emphasis is given on their application in organic synthesis for the resolution of racemates and prostereogenic compounds.

2002年12月1日 · Carboxyl ester lipase (CEL), previously named pancreatic cholesterol esterase and also known as bile salt-stimulated (or -dependent) lipase, is a nonspecific lipolytic enzyme capable of hydrolyzing cholesteryl esters, tri-, di-, and mono-acylglycerols, phospholipids, lysophospholipids, and ceramide (1, 2, 3). The hydrolysis of water-insoluble ...

2022年2月28日 · A carboxylic acid ester is an ester derived from a carboxylic acid, which has the following general structural formula. eg: The O=C—O group in a carboxylic acid ester is called the carboxylic acid ester group. Carboxylic acid esters are …

Carboxyl ester lipase (CEL), previously named cholesterol esterase or bile salt-stimulated (or dependent) lipase, is a lipolytic enzyme capable of hydrolyzing cholesteryl esters, tri-, di-, and mono-acylglycerols, phospholipids, lysophospholipids, and ceramide.