2021年2月1日 · Jersey haplotype (JH) 1, a stop-gain lethal mutation in the CWC15 gene, causes embryonic losses in Jersey cattle. Two PCR based assays using Amplification Refractory Mutation System (T-ARMS-PCR) and restriction fragment length polymorphism (PCR-RFLP) were developed for screening of the JH1 in cattle.

Designated in June of 2011, Jersey Haplotype 1 (JH1) was initially mapped as a 73‐marker haplotype on Bos taurus autosome 15 (technical label BTA15) based on fertility records of 830,391 Jersey females. AIPL geneticists found that JH1 was associated with average reduction in conception rate of 3.7%.

2015年7月15日 · An autosomal recessive genetic defect termed JH1 has been associated with early embryonic loss in the Jersey cattle breed. The genetic basis has been identified as a cytosine to thymine mutation...

2022年9月1日 · An activating JAK2 V617F mutation occurs in 95% of people with polycythemia vera and about 50% of cases of myelofibrosis and essential thrombocythemia. Abrocitinib, ruxolitinib, and upadacitinib are JAK inhibitors that are …

2024年8月21日 · JH1 is approximately 275 amino acids in length and encodes a protein kinase that constitutes the catalytic domain responsible for phosphorylating substrate molecules.

2009年4月6日 · In wild-type JAK2, the activation loop of JAK2-homology domain 1 (JH1) is pulled toward the JH1/JH2 interface through interactions with key residues of JH2, especially S591, F595, and V617, and stabilizes the inactivated form of JH1.

To screen for JH1 carriers in an imported Jersey population in China, a method based on a polymerase chain reaction amplification followed by a restriction fragment length polymorphism assay (PCR-RFLP) was developed for the accurate diagnosis of the JH1 allele.

An autosomal recessive genetic defect termed JH1 has been associated with early embryonic loss in the Jersey cattle breed. The genetic basis has been identified as a cytosine to thymine mutation in the CWC15 gene that changes an amino acid from arginine to a stop code.

2015年7月15日 · An autosomal recessive genetic defect termed JH1 has been associated with early embryonic loss in the Jersey cattle breed. The genetic basis has been identified as a cytosine to thymine mutation in...

2013年10月31日 · Recently, scientists working at the USDA Animal Improvement Programs Laboratory (USDA-AIPL) have discovered a specific haplotype associated with infertility in Jerseys called JH1. A haplotype is one or more alleles at closely located positions on a chromosome that are inherited together.