Catalpol - an overview | ScienceDirect Topics
Catalpol is an iridoid compound with a polar structure, as illustrated in Fig. 1. Due to the presence of polar functional groups, catalpol is highly hydrophilic and soluble in both water and …
Protective effects of catalpol on cardio-cerebrovascular diseases: A ...
2023年10月1日 · Catalpol, an iridoid glucoside isolated from Rehmannia glutinosa, has gained attention due to its potential use in treating cardio-cerebrovascular diseases (CVDs). This …
Catalpol rescues cognitive deficits by attenuating amyloid β …
2023年9月1日 · Catalpol potently inhibited Aβ fibril and oligomer formation. In microglial cells stimulated by Aβ, catalpol alleviated the expression of the proinflammatory cytokines tumor …
Therapeutic potential of catalpol and geniposide in Alzheimer’s …
2021年9月1日 · The catalpol was slowly eliminated with the AUC CSF /AUC plasma of 5.8 % and T 1/2 of 1.5 h, demonstrating that portions of catalpol could pass the blood-brain barrier. A …
Catalpol attenuates ischemic stroke by promoting neurogenesis …
2024年6月1日 · Catalpol increases the number of newborn neurons and the expressions of MAP2 and GAP–43 in the cortex around ischemia in rats. (A and B) MAP2 + /BrdU + double–positive …
Catalpol alleviates hypoxia ischemia-induced brain damage by …
2024年4月5日 · Catalpol is an iridoid glucoside isolated from Rehmannia (Jiang et al., 2015). Several studies demonstrated the neuroprotective effects of catalpol in neurodegenerative …
Catalpol ameliorates LPS-induced inflammatory response by …
2023年12月5日 · Although catalpol has been shown to ameliorate endoplasmic reticulum stress in 2, 4, 6-trinitrobenzene sulfonic acid (TNBS) -induced colitis (Xiong et al., 2017), the protective …
Catalpol rescues LPS-induced cognitive impairment via inhibition …
2024年1月30日 · Also, catalpol reduced cognitive impairment caused by LPS damage dose-dependently (Fig. 1). Besides, according to LC-MS/MS analysis, catalpol had a 136 ng/mg …
Catalpol ameliorates hepatic insulin resistance in type 2 diabetes ...
2018年4月1日 · Type 2 diabetes is characterized by insulin resistance in target tissues and hyperglycemia. Catalpol is a natural product isolated from the root of Rehmannia glutinosa, …
Inhibitory effects of catalpol on DNCB-induced atopic dermatitis …
2024年1月5日 · Catalpol inhibited MCs activation and allergic responses in vitro and in vivo. And catalpol alleviated DNCB-induced AD-like skin lesions via regulation of pro-Th2 and Th2 …