Cathepsin D - Wikipedia
Cathepsin D is an aspartic endo-protease that is ubiquitously distributed in lysosomes. [7] The main function of cathepsin D is to degrade proteins and activate precursors of bioactive proteins in pre-lysosomal compartments. [8]
The noncanonical role of the protease cathepsin D as a cofilin ...
2021年1月29日 · Cathepsin D (cathD) is traditionally regarded as a lysosomal protease that degrades substrates in acidic compartments. Here we report cathD plays an unconventional role as a cofilin phosphatase...
CTSD Gene - GeneCards | CATD Protein | CATD Antibody
2024年12月24日 · CTSD (Cathepsin D) is a Protein Coding gene. Diseases associated with CTSD include Ceroid Lipofuscinosis, Neuronal, 10 and Neuronal Ceroid Lipofuscinosis . Among its related pathways are Peptide hormone metabolism and ESR-mediated signaling .
CATHEPSIN D – MANY FUNCTIONS OF ONE ASPARTIC …
Cathepsin D (CD) is a soluble lysosomal aspartic endopeptidase (EC 3.4.23.5) synthesized in rough endoplasmic reticulum as preprocathepsin D.
Cathepsin D as a potential therapeutic target to enhance ... - Nature
2022年2月4日 · Cathepsin D (Cat D), a protein predominantly localized in lysosomes, performs multiple biological functions, such as degradation of intracellular and extracellular proteins, regulation of cell...
Cathepsin D: A cellular roadmap - ScienceDirect
2008年11月7日 · Cathepsin D is a normal and major component of lysosomes, it is found in almost all cells and tissues of mammals. Present review describes different events in cellular life of cathepsin D mainly its biosynthesis, co-translational and posttranslational modifications, targeting to lysosomes and proteolytic processing and maturation within lysosomes.
Identification of Cathepsin D as a Plasma Biomarker for …
Cathepsin D encoded by the CTSD gene is a lysosomal aspartic acidic protease. It exists as a diglycosylated precursor form (pro-cathepsin D) in the Golgi complex. Once pro-cathepsin D loses its inhibitory signal peptide, it becomes a mature and active enzymatic form through further processing in the lysosome [9,10,11]. Lysosomal cathepsin D ...
Cathepsin D—Managing the Delicate Balance - MDPI
2021年6月5日 · Lysosomal proteases play a crucial role in maintaining cell homeostasis. Human cathepsin D manages protein turnover degrading misfolded and aggregated proteins and favors apoptosis in the case of proteostasis disruption. However, when cathepsin D regulation is affected, it can contribute to numerous disorders.
The multifaceted roles of cathepsins in immune and inflammatory ...
2024年12月31日 · The cathepsin family comprises lysosomal proteases that play essential roles in various physiological processes, including protein degradation, antigen presentation, apoptosis, and tissue remodeling. Dysregulation of cathepsin activity has been linked to a variety of pathological conditions, such as cancer, autoimmune diseases, and neurodegenerative …
The Role of Cathepsin D in the Pathogenesis of Human …
2016年4月26日 · The lysosomal proteolytic enzyme Cathepsin D is the only aspartic-type protease ubiquitously expressed in all the cells of the human body, and it is expressed at high level in the brain. In general, cathepsin D mediated proteolysis is essential to neuronal cell homeostasis through the degradation of unfolded or oxidized protein aggregates ...
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