Core binding factor acute myeloid leukaemia is a cancer related to genetic changes in the CBF gene. It is most commonly caused by an inversion of particular region of chromosome 16; however it can also be caused by translocation between copies of chromosome 16. The rearrangements cause formation of CBF but with impaired function.

2025年2月9日 · CBFbeta is essential for TEL-AML1's ability to promote self-renewal of B cell precursors in vitro. high CBFB protein level was an independent predictor of survival in colorectal cancer interaction with PEBP2-beta leads to the phosphorylation of RUNX1, which in turn induces p300 phosphorylation

2024年12月24日 · CBFB (Core-Binding Factor Subunit Beta) is a Protein Coding gene. Diseases associated with CBFB include Cleidocranial Dysplasia 2 and Acute Myeloid Leukemia With Abnormal Bone Marrow Eosinophils Inv (16) (P13q22) Or T (16;16) (P13;Q22).

2010年6月30日 · CBFbeta is a transcriptional co-activator that is recruited to promoters by Runx transcription factors and there is considerable evidence that CBFbeta is essential for the function of Runx factors. However, overexpression of Runx1 can partially rescue the lethal phenotype in CBFbeta-deficient mice, indicating that increased levels of Runx ...

CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation.

HIV-1 Vif, CBF-beta, CUL5, and ELOB/C form a complex that is required for Vif-mediated downregulation of A3G and A3F. CBF-beta regulates HIV-1 infectivity only in the presence of A3G. The interaction of HIV-1 Vif with EloB/EloC complex is important for the binding of Vif to CBF-beta in cells.

Mammalian core binding factor beta (CBFbeta) and Drosophila Brother (Bro) and Big-brother (Bgb) proteins are transcription factors that dimerize with mammalian Runx and Drosophila Runt and Lozenge proteins and augment their DNA binding affinity and transcriptional potency. CBFbeta is essential for d …

The CBFbeta subunit is the non-DNA-binding subunit of the heterodimeric core-binding factor (CBF). CBFbeta associates with DNA-binding CBFalpha subunits and increases their affinity for DNA. Genes encoding the CBFbeta subunit (CBFB) and one of the CBFalpha subunits (CBFA2, otherwise known as AML1) are the most frequent targets of chromosomal ...

2010年6月30日 · CBFβ is a transcriptional co-activator that is recruited to promoters by Runx transcription factors and there is considerable evidence that CBFβ is essential for the function of Runx factors.

Cbfb（GFP / GFP）小鼠在软骨内和膜内骨化以及软骨细胞分化中表现出延迟，类似于但不如在Runx2（-/-）小鼠中观察到的延迟严重。我们证明，Cbfbeta在发育中的骨中表达并与Runx2形成功能相互作用，并且Cbfb（GFP）是一个亚等位基因。