CBL-B is an E3 ubiquitin-protein ligase that in humans is encoded by the CBLB gene. [5][6] CBLB is a member of the CBL gene family. CBL-B functions as a negative regulator of T-cell activation. [7] .

RING E3 泛素连接酶 Cbl 家族的分子 "守门员"（如 Cbl-b）在调节 T、B 和 NK 细胞的免疫激活过程中发挥着关键作用。基因靶向方法证明了Cbl-b负向调节T细胞功能的作用。

2023年12月16日 · Cbl-b is a RING-type E3 ubiquitin ligase that is expressed in several immune cell lineages, where it negatively regulates the activity of immune cells. Cbl-b has specifically been identified...

2024年12月24日 · CBLB (Cbl Proto-Oncogene B) is a Protein Coding gene. Diseases associated with CBLB include Autoimmune Disease, Multisystem, Infantile-Onset, 3 and Thrombocythemia 1. Among its related pathways are Class I MHC mediated antigen processing and presentation and Angiopoietin-like protein 8 regulatory pathway.

E3连接酶Cbl-b是CD28介导的信号传导的主要抑制剂，从机制上讲，E3连接酶Cbl-b通过结合和泛素化PI3K的p85β亚单位来抑制CD28依赖的PI3K途径。 E3连接酶不仅能阻碍CD28信号传导，而且能促进CD28信号传导。

In this brief review, we summarize the major work that we and others have carried out investigating Cbl-b in T cell tolerance and autoimmunity, proallergic T cell development, and cancer immunity.

2023年4月23日 · 据先声再明首席科学官Tamas Oravecz博士介绍，E3泛素连接酶CBL-b（Casitas B细胞淋巴瘤蛋白b）在多种免疫细胞内表达，通过促进泛素化作用，导致下游信号蛋白（如Vav1，PLCγ）降解，负向调节免疫功能。

2022年7月12日 · NX-1607是一种Casitas B系淋巴瘤原癌基因（CBL-B）抑制剂。NX-1607作用于T细胞、NK细胞和树突状细胞以增强抗肿瘤免疫力，在多种肿瘤模型中显示出单药抗肿瘤活性。

2024年8月12日 · Casitas B-lymphoma proto-oncogene-b (Cbl-b) is a RING finger E3 ligase that has an important role in effector T cell function, acting as a negative regulator of T cell, natural killer (NK) cell, and B cell activation.

2024年1月6日 · Cbl-b全名Casitas B lymphoma-b（Uniprot ID Q13191），是一种RING-type E3泛素蛋白连接酶，属于CBL家族的成员，在人类中由CBLB基因编码。 E3 泛素蛋白连接酶，从特定的E2泛素结合酶中接受泛素，并将其转移到底物上，从而促进蛋白酶体对底物的降解。