2024年12月24日 · CCL24 (C-C Motif Chemokine Ligand 24) is a Protein Coding gene. Diseases associated with CCL24 include Vernal Keratoconjunctivitis and Allergic Asthma. Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include cytokine activity and chemokine activity.

CCL24 is a small cytokine belonging to the CC chemokine family. CCL24 interacts with chemokine receptor CCR3 to induce chemotaxis in eosinophils. [3] . This chemokine is also …

CCL24, also known as eosinophil chemotactic protein 2 (eotaxin-2) and myeloid progenitor inhibitory factor 2 (MPIF-2), is a small cytokine of the CC chemokine family, located on chromosome 7 in the human genome.

浙江大学医学院附属第一医院马量老师团队 在《Cell Biol Toxicol》发表了题目为：CCL24/CCR3 axis plays a central role in angiotensin II-induced heart failure by stimulating M2 macrophage polarization and fibroblast activation的研究论文，本研究旨在探讨多效性趋化因子CCL24在心力衰竭中的作用机制。 简介： 心力衰竭（HF）具有较高的发病率和死亡率，不仅降低心脏的泵血能力，而且阻碍心脏电传导。 因此，迫切需要揭示心力衰竭的原因，并找到一种有效的治疗方法 …

Of many chemokines, C-C motif chemokine ligand 24 (CCL24) has been shown to contribute to tumorigenesis as well as inflammatory diseases like asthma, allergies, and eosinophilic esophagitis. CCL24 is expressed in some tumor cells such as colon cancer, hepatocellular carcinoma, and cutaneous T cell lymphoma.

CCL24/CCR3 axis plays a central role in angiotensin II-induced heart failure by stimulating M2 macrophage polarization and fibroblast activation. CCL24, CXCL9 and CXCL10 are increased in synovial fluid in patients with juvenile idiopathic arthritis requiring advanced treatment.

2021年7月22日 · Of many chemokines, C-C motif chemokine ligand 24 (CCL24) has been shown to contribute to tumorigenesis as well as inflammatory diseases like asthma, allergies, and eosinophilic esophagitis. CCL24 is expressed in some tumor cells such as colon cancer, hepatocellular carcinoma, and cutaneous T cell lymphoma.

由该基因编码的细胞因子对静息 T 淋巴细胞显示趋化活性，对嗜中性粒细胞具有最小活性，对单核细胞和活化 T 淋巴细胞呈阴性。 这种蛋白质还具有抗菌活性，对肺炎链球菌、金黄色葡萄球菌、不可分型流感嗜血杆菌和铜绿假单胞菌显示出抗菌作用。 最后，该蛋白质是多能造血祖细胞系集落形成的强抑制剂。 [RefSeq 提供，2020 年 7 月] This gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory …

2024年6月1日 · CM-101, a humanized monoclonal antibody, successfully neutralizes C-C motif chemokine ligand 24 (CCL24), a key factor linked to inflammatory and fibrotic diseases. Phase 1a studies involving both intravenous (IV) and subcutaneous (SC) administration of CM-101 in healthy participants demonstrated rare and mild adverse events.

2025年2月8日 · CCL24 regulates biliary inflammation and fibrosis in primary sclerosing cholangitis. CCL24 Protects Renal Function by Controlling Inflammation in Podocytes. M2-like, dermal macrophages are maintained via IL-4/CCL24-mediated cooperative interaction with eosinophils in cutaneous leishmaniasis.