2022年8月12日 · FTO, as an m 6 A mRNA demethylase, is involved in various cancers. However, the role of FTO in clear cell renal cell carcinoma (ccRCC) remains unclear. In the present study, we discovered...

This study explored the impact of FTO on the progression of ccRCC and identified elevated FTO expression in tumor tissues. Mechanistic investigations revealed that downregulating FTO could inhibit ccRCC cell proliferation and impair its DDR function.

2020年8月19日 · To investigate the functional role of FTO in VHL wild type and VHL-deficient ccRCC tumor growth and survival, we performed loss-of-function studies with a genetic approach to knock down FTO expression in ccRCC isogenic cell lines that are VHL-deficient (786-OM1A-vec and UMRC2-vec) or VHL-reconstituted (786-OM1A-VHL, UMRC2-VHL).

Here, we demonstrate that fat mass and obesity associated (FTO), as an m6A demethylase, plays a critical anti‐tumorigenic role in clear cell renal cell carcinoma (ccRCC). FTO is suppressed in ccRCC tissue. The low expression of FTO in human ccRCC correlates with increased tumour severity and poor patient survival.

2024年1月25日 · FTO could potentially serve as a diagnostic marker for ccRCC. FTO promotes the progression of ccRCC by regulating m⁶A modification, making the inhibition of FTO a potential novel therapeutic strategy in ccRCC.

2024年1月25日 · FTO promotes the progression of ccRCC by regulating m6A modification, making the inhibition of FTO a potential novel therapeutic strategy in ccRCC. As the first identified m6A demethylase, FTO has been implicated in the progression of various cancers.

2023年3月15日 · In the present study, we investigated the effects of m 6 A demethylases FTO and ALKBH5 on renal cell carcinoma (RCC) cell lines. Methods: The epithelial-mesenchymal in vitro knockdowns of FTO and ALKBH5 induced by antisense oligonucleotides (LNA-GapmeR system) were established in RCC cell lines.

2022年8月27日 · Some studies demonstrated that decreased FTO expression was associated with aggressive clinical features and shorter overall survival in clear cell RCC (ccRCC) patients, while others found that FTO inhibition selectively reduced the growth and survival of VHL-deficient ccRCC cells in vitro and in vivo. Here, we review the evidence supporting ...

2022年10月3日 · Our findings uncovered the crucial role of FTO/autophagy/SIK2 axis in modulating the progression of ccRCC, suggesting that FTO may serve as a valuable prognostic biomarker and promising therapeutic target in ccRCC.

2022年3月1日 · Here we show that miR-155 directly targets FTO to negatively regulate its expression and increased m 6 A level in ccRCC. Combining bioinformatics analysis and luciferase reporter assays, we identified that miR-155 directly bound to the 3′UTR of FTO mRNA and reduced FTO protein levels in ccRCC cells.