The m6A modification-mediated OGDHL exerts a tumor …
2023年8月25日 · Mechanistic studies revealed that FTO inhibits OGDHL expression in ccRCC through RNA m6A methylation, which downregulates FASN, leading to lipid accumulation and ERK pathway activation.
The m6A modification-mediated OGDHL exerts a tumor …
2023年8月25日 · Mechanistic studies revealed that FTO inhibits OGDHL expression in ccRCC through RNA m6A methylation, which downregulates FASN, leading to lipid accumulation and ERK pathway activation. We propose that the FTO/OGDHL/FASN/ERK signaling axis enriches our current understanding of ccRCC progression and …
Von Hippel Lindau tumor suppressor controls m6A-dependent …
2024年4月15日 · Evidence suggests that the dysregulated N6-methyladenosine on RNA (m6A) is involved in the initiation and progression of renal cancers , suggesting a potential therapeutic opportunity for ccRCC. The m6A represents a most prevalent modification of mRNA in …
VHL governs m6A modification and PIK3R3 mRNA stability in
2024年4月15日 · N6-Methyladenosine (m6A), a prevalent posttranscriptional modification, plays an important role in cancer progression. Clear cell renal cell carcinoma (ccRCC) is chiefly associated with the loss of the von Hippel-Lindau (VHL) gene, encoding a component of the E3 ubiquitin ligase complex. In this iss …
m6A Methylation Patterns and Tumor Microenvironment …
2022年4月21日 · Our findings thoroughly elucidated that m6A modification contributes to tumor microenvironment immune-infiltrating characteristics and prognosis in ccRCC. Assessing the m6A modification patterns of individual patients with ccRCC will offer novel insights into TME infiltration and help develop more effective treatment strategies.
METTL14-mediated N6-methyladenosine modification of Pten …
2022年3月5日 · Clear-cell renal-cell carcinoma (ccRCC) is one of the leading causes of tumour-related death worldwide. Methyltransferase-like 14 (METTL14) is reported...
The m6A demethylase FTO targets POLQ to promote ccRCC cell
2024年1月25日 · FTO promotes the progression of ccRCC by regulating m 6 A modification, making the inhibition of FTO a potential novel therapeutic strategy in ccRCC. FTO could potentially serve as a diagnostic marker for ccRCC.
DMDRMR-Mediated Regulation of m6A-Modified CDK4 by m6A …
2021年2月15日 · In patients with ccRCC, high coexpression of DMDRMR and IGF2BP3 was associated with poor outcomes. Our findings reveal that DMDRMR cooperates with IGF2BP3 to regulate target genes in an m 6 A-dependent manner and may represent a potential diagnostic, prognostic, and therapeutic target in ccRCC.
revealed that FTO inhibits OGDHL expression in ccRCC through RNA m6A methylation, which downregulates FASN, leading to lipid accumulation and ERK pathway activation. We propose that
The m6A demethylase FTO targets POLQ to promote ccRCC cell
2024年1月25日 · As the first identified m6A demethylase, FTO has been implicated in the progression of various cancers. However, the specific mechanism of FTO in clear cell renal cell carcinoma (ccRCC) remains incompletely understood. In this study, we aimed to explore the potential molecular mechanisms influencing the progression of ccRCC.