The Cancer Genome Atlas Comprehensive Molecular Characterization of ...
To highlight the most meaningful somatic alterations in the entire cohort and within each major histologic subtype, we performed an integrated comparative genomic analysis of all available histologically confirmed TCGA samples of ccRCC, PRCC, and ChRCC to identify shared and subtype-specific molecular features that will provide the foundation ...
Comprehensive molecular characterization of clear cell renal cell ...
2013年6月23日 · We accrued more than 500 primary nephrectomy specimens from patients with histologically confirmed ccRCC that conformed to the requirements for genomic study defined by the Cancer Genome Atlas...
The Cancer Genome Atlas of renal cell carcinoma: findings and
2019年7月5日 · The Cancer Genome Atlas (TCGA) characterized the somatic genetic and genomic alterations in renal cell carcinoma (RCC) encompassing the major RCC histological...
Multi-omic profiling of clear cell renal cell carcinoma identifies ...
2024年2月15日 · Here we perform genomic, transcriptomic, proteomic, metabolomic and spatial transcriptomic and metabolomic analyses on 100 patients with ccRCC from the Tongji Hospital RCC (TJ-RCC) cohort. Our...
学术前沿 | 单细胞转录组学揭示myCAF细胞与ccRCC疾病进展和免 …
2025年2月5日 · 免疫检查点抑制剂 （Immune checkpoint inhibitors，ICI）是治疗转移性 肾透明细胞癌 （clear cell renal cell carcinoma，ccRCC） 的基石，然而仅有部分患者对ICI具有良好的响应，准确了解肿瘤细胞的可塑性及其与肿瘤微环境的相互作用可以更好地预测ICI的治疗效果并有针对性的设计个性化的治疗方案。 为此，研究者对ccRCC患者的肿瘤和正常邻近组织 （normal adjacent tissue，NAT） 进行了单细胞转录组测序，共鉴定出46个细胞亚群，其中5个肿瘤细胞 …
Transcriptomic characterization and innovative molecular classification ...
2020年9月22日 · We performed whole-transcriptomic sequencing on 55 tumor tissues and 11 matched normal tissues from Chinese ccRCC patients. We systematically analyzed the data from our cohort and comprehensively compared with the TCGA ccRCC cohort.
The Cancer Genome Atlas of renal cell carcinoma: findings and …
The Cancer Genome Atlas (TCGA) characterized the somatic genetic and genomic alterations in renal cell carcinoma (RCC) encompassing the major RCC histological subtypes, including clear cell RCC (ccRCC), papillary RCC (pRCC) and chromophobe RCC (chRCC).
文献解读|Nat Genet（30.8）：透明细胞肾细胞癌的多组学分析确 …
2024年2月15日 · 本项研究对来自TJ-RCC队列的 100 名 ccRCC 患者进行基因组、转录组、蛋白质组、代谢组以及空间转录组，确定了四种 ccRCC 亚型，包括去透明细胞分化 (DCCD)-ccRCC，这是一种具有独特代谢特征的亚型。
学术前沿 | 单细胞多组学分析揭示肾透明细胞癌关键转录因子调控 …
研究者应用 单细胞转录组测序 （scRNA-seq）和 单细胞转座酶可及染色质测序 （scATAC-seq）描绘了ccRCC的肿瘤微环境（tumor microenvironment, TME）转录组和表观遗传图谱。 在此基础上，研究者确定了四个介导肿瘤细胞特异性调节机制且具有预后价值的关键转录因子（transcript factors, TFs）（HOXC5 、 VENTX 、 ISL1 和 OTP）。 在后续实验中，研究者发现靶向上述转录因子可以减少肿瘤细胞的增殖。 与此同时，多组学联合分析描述了CD8+ T细胞 …
Study on the mechanism of BGN in progression and metastasis of ccRCC
2025年3月19日 · Clear cell renal cell carcinoma (ccRCC) is the predominant histological subtype of renal cell carcinoma (RCC), representing approximately 75% of all RCC cases, which is a prevalent urinary system malignancy characterized by a high metastasis rate and a dismal 5-year survival rate following metastasis [1, 2].In 2022, China and the United States recorded over 70,000 new ccRCC cases, with ...